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Iseganan

Iseganan is a synthetic analog of a peptide, and with broad-spectrum antimicrobial activity. It is under development for the prevention of oral mucositis from chemotherapy and radiation therapy.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-184

CAS No:257277-05-7

Synonyms/Alias:Iseganan;257277-05-7;Antimicrobial peptide IB-367;Iseganan [INN];IB-367;UNII-Q9SAI36COS;IB 367;DTXSID80180415;IB-367-03;L-Argininamide, L-arginylglycylglycyl-L-leucyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginylglycyl-L-arginyl-L-phenylalanyl-L-cysteinyl-L-valyl-L-cysteinyl-L-valylglycyl-, cyclic (5-14),(7-12)-;isegananum;ISEGANAN [MI];Q9SAI36COS;ISEGANAN [WHO-DD];CHEMBL2110753;GTPL10822;DTXCID90102906;EX-A7465;DA-64513;NS00121746;ARG-GLY-GLY-LEU-CYS-TYR-CYS-ARG-GLY-ARG-PHE-CYS-VAL-CYS-VAL-GLY-ARG-NH2, CYCLIC (5-14, 7-12) DISULFIDE;L-ARGININAMIDE, L-ARGINYLGLYCYLGLYCYL-L-LEUCYL-L-CYSTEINYL-L-TYROSYL-L-CYSTEINYL-L-ARGINYLGLYCYL-L-ARGINYL-L-PHENYLALANYL-L-CYSTEINYL-L-VALYL-L-CYSTEINYL-L-VALYLGLYCYL-, CYCLIC (5->14), (7->12)-BIS(DISULFIDE);

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C78H126N30O18S4
M.W/Mr.
1900.3
Sequence
One Letter Code:RGGLCYCRGRFCVCVGR
Three Letter Code:H-Arg-Gly-Gly-Leu-Cys(1)-Tyr-Cys(2)-Arg-Gly-Arg-Phe-Cys(2)-Val-Cys(1)-Val-Gly-Arg-NH2
Application
Antibacterial.
Biological Activity
Iseganan, an antimicrobial peptide, is active against aerobic and anaerobic gram-positive and gram-negative bacteria as well as fungi and yeasts.
Source#
Synthetic
InChI
InChI=1S/C78H126N30O18S4/c1-39(2)28-49(99-57(111)32-93-56(110)31-94-63(115)45(79)16-10-24-89-75(81)82)66(118)103-53-36-128-130-38-55(72(124)107-60(40(3)4)73(125)96-34-58(112)97-46(62(80)114)17-11-25-90-76(83)84)106-74(126)61(41(5)6)108-71(123)54-37-129-127-35-52(104-68(120)51(102-70(53)122)30-43-20-22-44(109)23-21-43)69(121)100-47(18-12-26-91-77(85)86)64(116)95-33-59(113)98-48(19-13-27-92-78(87)88)65(117)101-50(67(119)105-54)29-42-14-8-7-9-15-42/h7-9,14-15,20-23,39-41,45-55,60-61,109H,10-13,16-19,24-38,79H2,1-6H3,(H2,80,114)(H,93,110)(H,94,115)(H,95,116)(H,96,125)(H,97,112)(H,98,113)(H,99,111)(H,100,121)(H,101,117)(H,102,122)(H,103,118)(H,104,120)(H,105,119)(H,106,126)(H,107,124)(H,108,123)(H4,81,82,89)(H4,83,84,90)(H4,85,86,91)(H4,87,88,92)/t45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,60-,61-/m0/s1
InChI Key
GUCYBPFJNGVFEB-XELKFLSISA-N

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