Iseganan

Name: Iseganan
Brand: Creative Peptides
SKU: 10-101-184
Availability: MadeToOrder

Iseganan is a synthetic analog of a peptide, and with broad-spectrum antimicrobial activity. It is under development for the prevention of oral mucositis from chemotherapy and radiation therapy.

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CAT No: 10-101-184

CAS No: 257277-05-7

Synonyms/Alias: Iseganan;257277-05-7;Antimicrobial peptide IB-367;Iseganan [INN];IB-367;UNII-Q9SAI36COS;IB 367;DTXSID80180415;IB-367-03;L-Argininamide, L-arginylglycylglycyl-L-leucyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginylglycyl-L-arginyl-L-phenylalanyl-L-cysteinyl-L-valyl-L-cysteinyl-L-valylglycyl-, cyclic (5-14),(7-12)-;isegananum;ISEGANAN [MI];Q9SAI36COS;ISEGANAN [WHO-DD];CHEMBL2110753;GTPL10822;DTXCID90102906;EX-A7465;DA-64513;NS00121746;ARG-GLY-GLY-LEU-CYS-TYR-CYS-ARG-GLY-ARG-PHE-CYS-VAL-CYS-VAL-GLY-ARG-NH2, CYCLIC (5-14, 7-12) DISULFIDE;L-ARGININAMIDE, L-ARGINYLGLYCYLGLYCYL-L-LEUCYL-L-CYSTEINYL-L-TYROSYL-L-CYSTEINYL-L-ARGINYLGLYCYL-L-ARGINYL-L-PHENYLALANYL-L-CYSTEINYL-L-VALYL-L-CYSTEINYL-L-VALYLGLYCYL-, CYCLIC (5->14), (7->12)-BIS(DISULFIDE);

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C78H126N30O18S4
M.W/Mr.	1900.3
Sequence	One Letter Code:RGGLCYCRGRFCVCVGR Three Letter Code:H-Arg-Gly-Gly-Leu-Cys(1)-Tyr-Cys(2)-Arg-Gly-Arg-Phe-Cys(2)-Val-Cys(1)-Val-Gly-Arg-NH2
Application	Antibacterial.
Biological Activity	Iseganan, an antimicrobial peptide, is active against aerobic and anaerobic gram-positive and gram-negative bacteria as well as fungi and yeasts.

Source#	Synthetic
InChI	InChI=1S/C78H126N30O18S4/c1-39(2)28-49(99-57(111)32-93-56(110)31-94-63(115)45(79)16-10-24-89-75(81)82)66(118)103-53-36-128-130-38-55(72(124)107-60(40(3)4)73(125)96-34-58(112)97-46(62(80)114)17-11-25-90-76(83)84)106-74(126)61(41(5)6)108-71(123)54-37-129-127-35-52(104-68(120)51(102-70(53)122)30-43-20-22-44(109)23-21-43)69(121)100-47(18-12-26-91-77(85)86)64(116)95-33-59(113)98-48(19-13-27-92-78(87)88)65(117)101-50(67(119)105-54)29-42-14-8-7-9-15-42/h7-9,14-15,20-23,39-41,45-55,60-61,109H,10-13,16-19,24-38,79H2,1-6H3,(H2,80,114)(H,93,110)(H,94,115)(H,95,116)(H,96,125)(H,97,112)(H,98,113)(H,99,111)(H,100,121)(H,101,117)(H,102,122)(H,103,118)(H,104,120)(H,105,119)(H,106,126)(H,107,124)(H,108,123)(H4,81,82,89)(H4,83,84,90)(H4,85,86,91)(H4,87,88,92)/t45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,60-,61-/m0/s1
InChI Key	GUCYBPFJNGVFEB-XELKFLSISA-N

1. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment

2. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs

3. Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

4. Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

5. Myotropic activity of allatostatins in tenebrionid beetles

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