Kisspeptin-10, rat contains aromatic, basic, and hydrophobic residues arranged to promote defined receptor-binding surfaces. The peptide supports investigations of helix formation, residue-residue coupling, and solvent-driven structural transitions. Researchers use it to map ligand-recognition motifs and examine conformational energetics. Its compact length enables high-resolution analysis.
CAT No: R2281
CAS No:478507-53-8
Synonyms/Alias:Kisspeptin-10, rat;478507-53-8;CHEMBL3422406;L-Tyrosinamide,L-tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-;Kisspeptin-10 (mouse, rat);SCHEMBL17345398;HY-P1197;BDBM50082075;AKOS024458053;DA-54639;CS-0028953;(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-carbamoylpropanamido]-3-(1H-indol-3-yl)propanamido]-N-[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}-2-hydroxyethyl]succinamide;
Kisspeptin-10, rat is a synthetic decapeptide corresponding to the biologically active fragment of the rat kisspeptin family, a class of neuropeptides known for their pivotal role in the regulation of reproductive endocrinology. As a peptide ligand for the G protein-coupled receptor GPR54 (KISS1R), it is instrumental in modulating the hypothalamic-pituitary-gonadal axis, making it a key tool for researchers investigating neuroendocrine signaling pathways. The compound's sequence and structure closely mimic the endogenous rat form, allowing for precise modeling of physiological processes in rodent systems. Its use is central to studies aiming to unravel the mechanisms underlying puberty onset, fertility regulation, and broader neuropeptide signaling networks.
Reproductive neuroendocrinology research: In experimental studies focused on reproductive physiology, Kisspeptin-10 is routinely employed to stimulate or modulate the activity of gonadotropin-releasing hormone (GnRH) neurons. By acting as a potent activator of KISS1R, the peptide enables researchers to dissect the upstream regulatory mechanisms that control GnRH secretion, luteinizing hormone (LH) surges, and subsequent reproductive events. Its application is particularly valuable in rodent models for elucidating the neurochemical cues that govern sexual maturation and fertility cycles.
Signal transduction studies: Kisspeptin-10 serves as a model ligand in the investigation of G protein-coupled receptor (GPCR) signaling, specifically targeting the KISS1R pathway. Through in vitro and ex vivo assays, scientists utilize the peptide to trigger downstream intracellular cascades, such as calcium mobilization and MAPK activation. These experiments provide critical insights into the molecular dynamics of neuropeptide-receptor interactions, receptor desensitization, and the cross-talk between kisspeptin signaling and other neuroendocrine modulators.
Peptide structure-activity relationship (SAR) analysis: As a well-characterized decapeptide, Kisspeptin-10 is frequently used in SAR studies to identify the key residues responsible for receptor binding affinity and agonist potency. By modifying specific amino acids or generating analogs, researchers can systematically assess how structural changes influence biological activity. These investigations inform the design of novel peptide mimetics with tailored functional profiles for basic and applied research.
Endocrine disruption and environmental toxicology: The peptide is utilized as a reference compound in studies assessing the impact of environmental chemicals or endocrine disruptors on reproductive signaling pathways. By comparing the effects of exogenous agents on kisspeptin-induced GnRH release or LH secretion, toxicologists can evaluate the potential for environmental factors to interfere with neuroendocrine homeostasis in rodent models. Such applications are critical for understanding the broader implications of environmental exposures on reproductive health.
Neuroscience and brain mapping: In neuroanatomical and functional mapping studies, Kisspeptin-10 is applied to localize and characterize kisspeptin-responsive neuronal populations within the hypothalamus and other brain regions. By combining peptide administration with electrophysiological recordings, immunohistochemistry, or in situ hybridization, researchers can delineate the distribution, connectivity, and physiological roles of kisspeptinergic circuits. This approach advances knowledge of how neuropeptide systems integrate with broader neural networks to regulate complex behaviors and homeostatic processes.
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