Kisspeptin-10, rat contains aromatic, basic, and hydrophobic residues arranged to promote defined receptor-binding surfaces. The peptide supports investigations of helix formation, residue-residue coupling, and solvent-driven structural transitions. Researchers use it to map ligand-recognition motifs and examine conformational energetics. Its compact length enables high-resolution analysis.
CAT No: R2281
CAS No:478507-53-8
Synonyms/Alias:Kisspeptin-10, rat;478507-53-8;CHEMBL3422406;L-Tyrosinamide,L-tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-;Kisspeptin-10 (mouse, rat);SCHEMBL17345398;HY-P1197;BDBM50082075;AKOS024458053;DA-54639;CS-0028953;(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-carbamoylpropanamido]-3-(1H-indol-3-yl)propanamido]-N-[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}-2-hydroxyethyl]succinamide;
Kisspeptin-10, rat is a synthetic decapeptide derived from the naturally occurring kisspeptin protein sequence found in rodents. As a critical regulator of the reproductive axis, this peptide is widely recognized for its role in modulating the hypothalamic-pituitary-gonadal (HPG) axis and influencing the secretion of gonadotropin-releasing hormone (GnRH). Its unique amino acid sequence enables it to bind to the GPR54 receptor, also known as the kisspeptin receptor, thereby initiating a cascade of intracellular events that are pivotal in reproductive endocrinology research. The stable structure and high specificity of Kisspeptin-10, rat make it an essential tool for dissecting neuroendocrine mechanisms in laboratory studies, particularly those focused on reproductive physiology, neurobiology, and related signaling pathways.
Reproductive Endocrinology Research: Kisspeptin-10 is extensively utilized in studies investigating the neuroendocrine control of reproduction in rodents. By administering this peptide to animal models, researchers can stimulate the release of GnRH, which in turn triggers the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This controlled activation allows scientists to study the feedback mechanisms, signaling pathways, and physiological outcomes associated with reproductive hormone regulation, providing valuable insights into fertility, puberty onset, and reproductive disorders. The peptide's ability to precisely modulate the HPG axis makes it indispensable for experimental protocols aimed at unraveling the intricacies of reproductive endocrinology.
Neurobiology and Brain Signaling Pathways: In the realm of neurobiology, rat Kisspeptin-10 serves as a potent tool for exploring the central nervous system's regulatory networks. Its interaction with the GPR54 receptor in the hypothalamus and other brain regions enables researchers to map neural circuits involved in hormone release, behavioral responses, and neuroendocrine integration. Studies employing this peptide have helped elucidate the molecular and cellular mechanisms underlying neuronal communication, synaptic plasticity, and the integration of environmental cues with physiological processes. By leveraging its receptor specificity, scientists can dissect the roles of kisspeptin signaling in both reproductive and non-reproductive neural functions.
Metabolic Regulation and Energy Homeostasis: Beyond its classical role in reproductive biology, Kisspeptin-10 has attracted attention for its involvement in metabolic regulation. Research indicates that kisspeptin signaling can influence energy balance, appetite control, and glucose metabolism in rodent models. Experimental administration of the peptide allows investigators to assess its effects on metabolic pathways, energy expenditure, and the interplay between reproductive status and metabolic health. These studies contribute to a broader understanding of how neuropeptides coordinate physiological processes, shedding light on the complex relationships between metabolism, nutrition, and reproductive function.
Pharmacological Screening and Drug Discovery: The rat-derived decapeptide is also employed in pharmacological studies aimed at identifying novel modulators of the kisspeptin-GPR54 pathway. By using it as a reference ligand or agonist in receptor binding assays, researchers can screen for small molecules, peptides, or biologics that either enhance or inhibit kisspeptin signaling. Such investigations are vital for the development of therapeutic agents targeting reproductive or metabolic disorders, as well as for probing the structure-activity relationships governing receptor-ligand interactions. The peptide's well-characterized activity profile makes it a reliable standard in high-throughput screening and mechanistic pharmacology.
Comparative Physiology and Evolutionary Biology: Kisspeptin-10, rat is frequently used in comparative studies that examine the conservation and divergence of reproductive signaling pathways across species. By comparing the effects of this peptide in rodents with those observed in other vertebrates, researchers can gain insights into the evolutionary pressures shaping neuroendocrine regulation. These investigations help clarify the adaptive significance of kisspeptin signaling, the molecular evolution of peptide-receptor interactions, and the broader context of reproductive strategies in mammals and other taxa. The availability of species-specific peptides like rat Kisspeptin-10 enables precise experimental designs that advance our understanding of evolutionary biology and physiological adaptation.
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