L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide

Name: L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide
Brand: Creative Peptides
Rating: 5 (1 reviews)

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide is a reactive epoxysuccinyl peptide analog used to probe cysteine-based proteases. Its electrophilic moiety forms stable adducts for mechanistic enzyme studies. Researchers employ it to examine active-site geometry and irreversible inhibition processes. The compound aids structural mapping of catalytic pockets.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: L1901

CAS No:134448-10-5

Synonyms/Alias:CA-074;134448-10-5;MFCD00797531;CHEMBL490920;Cathepsin B Inhibitor III;(2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]formamido}pentanoyl]pyrrolidine-2-carboxylic acid;PrNH-tES-Ile-Pro-OH;CA 074 TFA;epoxysuccinyl derivative CA074;SCHEMBL4323476;BDBM16509;CA074;EX-A6724;AKOS024458382;CS-7886;N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline;AC-37063;DA-61987;FE111058;MS-26297;HY-103350;(L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline;L-Proline,N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-;N-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline;

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C18H29N3O6

M.W/Mr.

383.4

Sequence

One Letter Code:IP

InChI

InChI=1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-,13-,14-/m0/s1

InChI Key

ZEZGJKSEBRELAS-PEDHHIEDSA-N

1. High fat diet and GLP-1 drugs induce pancreatic injury in mice

2. Extended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate diet

3. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment

4. Myotropic activity of allatostatins in tenebrionid beetles

5. Emu oil in combination with other active ingredients for treating skin imperfections

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