LCKLSL

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
LCKLSL(CAS 533902-29-3)

CAT No: R1923

CAS No:533902-29-3

Synonyms/Alias:LCKLSL;533902-29-3;HY-P2333;AKOS040758181;CS-0130051;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C30H57N7O8S
M.W/Mr.
675.9
Sequence
One Letter Code:LCKLSL
Three Letter Code:H-Leu-Cys-Lys-Leu-Ser-Leu-OH
Application
Cardiovascular Disease
Activity
Inhibitor
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C30H57N7O8S/c1-16(2)11-19(32)25(39)37-24(15-46)29(43)33-20(9-7-8-10-31)26(40)34-21(12-17(3)4)27(41)36-23(14-38)28(42)35-22(30(44)45)13-18(5)6/h16-24,38,46H,7-15,31-32H2,1-6H3,(H,33,43)(H,34,40)(H,35,42)(H,36,41)(H,37,39)(H,44,45)/t19-,20-,21-,22-,23-,24-/m0/s1
InChI Key
HTBYABHLBWELKC-BTNSXGMBSA-N
References
1. Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64.

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