Linus cyclopeptide 9 contains a constrained cyclic topology that promotes conformational rigidity and resistance to unfolding. Aromatic and hydrophobic residues shape its interaction profile. Researchers study its binding specificity and structural transitions. Uses include cyclic-peptide engineering, structural biology, and natural-product analog development.
CAT No: R2682
CAS No:33302-55-5
Synonyms/Alias:Linus cyclopeptide 9;33302-55-5;cyclolinopeptide A;(9S,12S,15S,18S,21S,24S,27S,30S)-24,27-Dibenzyl-15-[(2S)-butan-2-yl]-9,12,21-tris(2-methylpropyl)-18-propan-2-yl-1,7,10,13,16,19,22,25,28-nonazatricyclo[28.3.0.03,7]tritriacontane-2,8,11,14,17,20,23,26,29-nonone;
Linus cyclopeptide 9 is a naturally occurring cyclic peptide belonging to the family of cyclolinopeptides, isolated from flaxseed (Linum usitatissimum). Distinguished by its unique cyclic structure and specific amino acid sequence, Linus cyclopeptide 9 exhibits remarkable stability and resistance to enzymatic degradation, making it an attractive candidate for a variety of biochemical and biotechnological applications. Its molecular architecture enables interactions with diverse biomolecules, facilitating research into peptide-membrane interactions, protein-protein binding, and signaling pathways. The compound's inherent bioactivity and physicochemical properties have positioned it as a valuable tool for scientists investigating natural product chemistry, peptide engineering, and molecular pharmacology.
Bioactive Compound Research: Linus cyclopeptide 9 serves as a model system for studying the structure-activity relationships of cyclic peptides. Researchers utilize it to elucidate how cyclic conformation and amino acid composition influence biological activity, guiding the rational design of novel peptide-based molecules. Its well-defined cyclic backbone allows for systematic modifications, enabling the exploration of functional group contributions and conformational constraints on peptide function. As a result, it has become integral to advancing knowledge in the field of natural bioactive peptides.
Peptide Drug Discovery: The unique properties of Linus cyclopeptide 9, such as its stability and membrane permeability, make it a promising lead compound for peptide drug discovery. Scientists leverage its scaffold to design and synthesize analogues with enhanced pharmacokinetic profiles, targeting a range of molecular pathways. By incorporating specific modifications, researchers aim to develop cyclopeptide derivatives with improved selectivity and potency against biological targets. Its application in early-stage drug screening and optimization underscores its potential as a template for next-generation peptide therapeutics.
Biochemical Tool Development: As a robust and structurally versatile molecule, Linus cyclopeptide 9 is frequently employed as a biochemical probe in academic and industrial laboratories. Its ability to interact with enzymes and cellular components makes it useful for dissecting molecular mechanisms underlying peptide recognition and processing. The compound's resistance to proteolysis facilitates its use in long-term assays and complex biological environments, enabling detailed kinetic and mechanistic studies without rapid degradation. This utility extends to the development of peptide-based biosensors and affinity reagents.
Food and Nutritional Science: In the context of food science, Linus cyclopeptide 9 is investigated for its potential functional roles in flaxseed-derived products. Researchers examine its impact on the nutritional profile, antioxidant properties, and stability of food formulations containing flaxseed extracts. The study of cyclolinopeptides in food matrices provides insights into their contribution to flavor, shelf life, and health-related attributes of plant-based ingredients. Its presence in dietary flaxseed products prompts further exploration of its interactions with other bioactive compounds and its influence on overall food quality.
Agricultural Biotechnology: Linus cyclopeptide 9 is also explored for its implications in plant defense and agricultural biotechnology. Scientists study its role in the natural defense mechanisms of flax plants, investigating its activity against pathogens and environmental stressors. Understanding the biosynthesis and function of cyclolinopeptides in plants can inform strategies for crop improvement, pest management, and the development of bioactive agricultural additives. The integration of such compounds into sustainable agricultural practices highlights their significance beyond traditional biochemical research.
In summary, Linus cyclopeptide 9's multifaceted applications span bioactive compound research, peptide drug discovery, biochemical tool development, food and nutritional science, and agricultural biotechnology. Its distinctive cyclic structure and bioactivity profile offer a versatile platform for advancing scientific inquiry and innovation across multiple disciplines, supporting ongoing efforts to harness the potential of natural peptides in research and industry.
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