Macrophage stimulatory lipopeptide 2 integrates a lipidated motif with a peptide backbone to explore membrane anchoring and pattern-recognition interactions. Its hydrophobic tail modifies solubility and structural dynamics. Researchers study conformational responses to lipid environments. Use spans immunopeptide modeling, biophysical studies, and ligand-pattern analysis.
CAT No: R2681
CAS No:250718-44-6
Synonyms/Alias:MALP-2;UNII-DZX5IUA94D;DZX5IUA94D;Macrophage-activating lipopeptide-2;250718-44-6;S-(2,3-Bispalmitoyloxy-(2R)-propyl)-cysteinly-gnndesnisfkek;L-Lysine, S-((2R)-2,3-bis((1-oxohexadecyl)oxy)propyl)-L-cysteinylglycyl-L-asparaginyl-L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-asparaginyl-L-isoleucyl-L-seryl-L-phenylalanyl-L-lysyl-L-alpha-glutamyl-;L-LYSINE, S-((2R)-2,3-BIS((1-OXOHEXADECYL)OXY)PROPYL)-L-CYSTEINYLGLYCYL-L-ASPARAGINYL-L-ASPARAGINYL-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-ASPARAGINYL-L-ISOLEUCYL-L-SERYL-L-PHENYLALANYL-L-LYSYL-L-.ALPHA.-GLUTAMYL-;S-[2,3-bispalmitoyloxy-(2R)-propyl]-cysteinly-GNNDESNISFKEK;L-Lysine, S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-asparaginyl-L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-asparaginyl-L-isoleucyl-L-seryl-L-phenylalanyl-L-lysyl-L-alpha-glutamyl-;macrophage stimulatory lipopeptide 2;S-(2,3-bispalmitoyloxypropyl)-CGNNDESNISFKEK;Macrophage-activating lipopeptide 2;HY-P10586;
Macrophage stimulatory lipopeptide 2 (MSLP-2) is a synthetic carbohydrate-based compound recognized for its potent immunomodulatory properties, particularly in the activation and regulation of macrophage function. As a unique lipopeptide, MSLP-2 features a distinctive molecular architecture that enables it to interact with pattern recognition receptors on immune cells, thus modulating various signaling pathways involved in innate immunity. Its amphipathic nature allows for efficient interaction with cell membranes, enhancing its biological activity and making it an invaluable tool for researchers studying host-pathogen interactions, immune response mechanisms, and cellular signaling. The product's stability and solubility in aqueous solutions further support its broad applicability in laboratory settings, facilitating a range of experimental designs from in vitro cell culture assays to ex vivo immune cell stimulation studies.
Immunological research: Macrophage stimulatory lipopeptide 2 serves as a powerful reagent in immunological investigations focused on elucidating the mechanisms of innate immune activation. By mimicking pathogen-associated molecular patterns, MSLP-2 is frequently employed to stimulate macrophages and dendritic cells in vitro, allowing researchers to dissect the downstream signaling cascades, such as NF-κB and MAPK pathways, that govern cytokine production and inflammatory responses. Its use in these studies helps clarify the roles of specific receptors, including toll-like receptors, in recognizing lipopeptide motifs and orchestrating immune defenses against microbial threats.
Vaccine adjuvant research: In the realm of vaccine development, MSLP-2 has garnered attention as a potential adjuvant candidate due to its capacity to enhance antigen-specific immune responses. Scientists incorporate this lipopeptide into experimental vaccine formulations to evaluate its ability to potentiate the activation and maturation of antigen-presenting cells, thereby promoting robust adaptive immunity. By studying its adjuvant effects, researchers aim to optimize vaccine efficacy and durability, particularly in the context of subunit or peptide-based immunogens that require additional immune stimulation for maximal protection.
Cell signaling pathway analysis: The use of macrophage stimulatory lipopeptide 2 extends to the detailed analysis of intracellular signaling networks. By selectively triggering innate immune receptors, MSLP-2 enables the examination of cross-talk between various signaling modules within immune cells. Researchers leverage its specificity to delineate the contributions of pathways such as PI3K/Akt and JAK/STAT in orchestrating cellular responses to external stimuli. This application is instrumental in mapping the dynamic regulatory circuits that underlie inflammation, immune cell differentiation, and pathogen defense.
Host-pathogen interaction models: MSLP-2 is integrated into experimental models designed to simulate host-pathogen interactions, providing insights into the molecular dialogues that occur during infection. By pre-activating macrophages or other immune cells, investigators can assess how these cells respond to subsequent microbial challenges, track the kinetics of cytokine release, and monitor the expression of surface markers associated with activation or polarization. Such studies contribute to a deeper understanding of immune evasion strategies employed by pathogens and inform the development of novel therapeutic interventions.
Drug screening and discovery: The compound plays a valuable role in drug discovery platforms aimed at identifying novel immunomodulatory agents. By using MSLP-2 as a standardized stimulant in high-throughput screening assays, pharmaceutical researchers can evaluate the efficacy of candidate molecules in modulating macrophage activation, cytokine secretion, or receptor signaling. This approach accelerates the identification of promising leads for further development in the field of immunotherapy and inflammation research, supporting the advancement of targeted therapies for immune-mediated diseases.
4. TMEM16F and dynamins control expansive plasma membrane reservoirs
5. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More