Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.
CAT No: R1510
CAS No:87218-84-6
Synonyms/Alias:MCH (salmon);87218-84-6;DTXSID40583241;PUBCHEM_16167455;MCH (salmon) trifluoroacetate salt;DA-65292;FM110322;H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH; H-DTMRCMVGRVYRPCWEV-OH;
Melanin Concentrating Hormone, salmon, is a peptide hormone originally isolated from salmon pituitary tissue and recognized for its pivotal role in the regulation of skin pigmentation and energy homeostasis in fish. As a member of the neuropeptide family, it functions as a signaling molecule influencing a range of physiological processes, particularly in teleosts. The peptide's unique sequence and conserved structure across species have made it a valuable model for comparative endocrinology and neurobiology research. Its relevance extends to studies of hormonal regulation, neuropeptide signaling, and the molecular mechanisms underlying pigment cell biology.
Neuroendocrine research: Melanin Concentrating Hormone from salmon is widely employed in neuroendocrinology to investigate the molecular signaling pathways involved in pigment regulation. By studying its action on melanophores, researchers can elucidate the mechanisms by which neuropeptides modulate skin coloration in fish. These investigations contribute to broader understanding of hormonal control in vertebrates, offering insight into neuropeptide receptor interactions and signal transduction processes.
Comparative physiology: The peptide's evolutionary conservation makes it a valuable tool for comparative studies across species. Researchers utilize it to explore the functional divergence and conservation of melanin-concentrating systems in teleosts and other vertebrates. Such comparative analyses help delineate the evolutionary adaptations of neuropeptidergic control over pigmentation, energy balance, and stress responses, enriching our understanding of vertebrate physiology.
Peptide receptor characterization: Experimental use of salmon-derived Melanin Concentrating Hormone allows for detailed characterization of its cognate receptors in model organisms. By applying the peptide in binding assays, cell-based functional studies, and receptor mapping experiments, scientists can dissect receptor-ligand interactions, downstream signaling events, and receptor distribution patterns. These insights are crucial for understanding neuropeptide-receptor specificity and the pharmacology of related signaling systems.
Peptide synthesis and analog development: The defined structure of salmon Melanin Concentrating Hormone serves as a reference for synthetic peptide production and analog design. Researchers engaged in peptide synthesis use the native sequence as a template for creating modified peptides to probe structure-activity relationships. Such work aids in the development of selective agonists or antagonists for experimental manipulation of melanin-concentrating systems, advancing peptide engineering and functional studies.
Biochemical assay development: The peptide is frequently utilized as a standard or control in biochemical assays designed to quantify neuropeptide activity, receptor binding, or downstream signaling events. Its well-characterized properties make it ideal for assay validation, calibration, and optimization in both in vitro and ex vivo systems. Incorporating salmon Melanin Concentrating Hormone into these protocols ensures reproducibility and accuracy in studies focused on neuropeptidergic signaling and pigment cell physiology.
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