Melanostatin DM is an inhibitor of α-melanocyte stimulating hormone (α-MSH), which is the primary hormone that controls production of melanin pigment.
CAT No: 10-101-221
CAS No:123689-72-5
Synonyms/Alias:Haatpln;123689-72-5;H-His-D-arg-ala-trp-D-phe-lys-NH2;Histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide;(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide;L-Lysinamide, L-histidyl-D-arginyl-L-alanyl-L-tryptophyl-D-phenylalanyl-;DTXSID00924570;(2S)-6-amino-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-5-carbamimidamidopentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanamido]hexanamide;(S)-2-((6R,9S,12S,15R)-12-((1H-indol-3-yl)methyl)-1-amino-6-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-15-benzyl-1-imino-9-methyl-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-amido)-6-aminohexanamide;1-Amino-18-(4-aminobutyl)-6-{[2-amino-1-hydroxy-3-(1H-imidazol-5-yl)propylidene]amino}-15-benzyl-7,10,13,16-tetrahydroxy-1-imino-12-[(1H-indol-3-yl)methyl]-9-methyl-2,8,11,14,17-pentaazanonadeca-7,10,13,16-tetraen-19-imidic acid;
Melanostatin DM is a synthetic peptide compound recognized for its role as an antagonist of melanocyte-stimulating hormone (MSH) receptors. As a member of the neuropeptide family, it is structurally designed to mimic endogenous regulatory peptides, enabling precise modulation of melanocortin signaling pathways. Its high specificity for MSH receptors renders it a valuable tool in molecular and cellular studies focused on pigmentation, neuroendocrine regulation, and receptor-ligand interactions. Researchers utilize this compound to dissect complex signaling cascades and to elucidate the biological functions governed by melanocortin pathways.
Receptor Binding Studies: Melanostatin DM is widely employed in receptor binding assays to investigate the affinity and selectivity of melanocortin receptor antagonists. By competitively inhibiting the interaction between endogenous MSH peptides and their receptors, it allows researchers to characterize binding kinetics and receptor pharmacology in both in vitro and ex vivo systems. This application is critical for mapping the functional domains of melanocortin receptors and for screening novel ligands with potential utility in neurobiological research.
Signal Transduction Research: The peptide's ability to selectively block MSH-induced signaling makes it an indispensable tool for dissecting intracellular pathways activated by melanocortin receptors. Investigators use Melanostatin DM to determine the downstream effects of receptor blockade on cyclic AMP production, protein kinase activation, and gene expression profiles. Such studies are essential for understanding the molecular mechanisms underlying pigmentation, appetite regulation, and stress responses at the cellular level.
Pigmentation Pathway Analysis: In pigmentation biology, Melanostatin DM serves as a key reagent for probing the regulatory processes governing melanin synthesis and distribution in melanocytes. By antagonizing MSH activity, it enables controlled inhibition of melanogenic pathways, facilitating the study of gene-environment interactions, pigment cell differentiation, and the impact of external factors on melanin production. This application supports research aimed at unraveling the genetic and biochemical determinants of skin and hair color.
Neuropeptide Functional Studies: The compound's structural similarity to endogenous neuropeptides makes it suitable for functional studies exploring neuroendocrine signaling networks. Researchers deploy Melanostatin DM to investigate the physiological roles of melanocortin antagonists in neuronal communication, behavioral modulation, and hormone secretion. These studies contribute to a deeper understanding of neuropeptide-mediated regulatory mechanisms in both central and peripheral tissues.
Peptide Drug Discovery and Development: Melanostatin DM is also utilized as a reference antagonist in the early stages of peptide-based drug discovery. Its defined activity profile provides a benchmark for evaluating the efficacy and selectivity of new synthetic peptides targeting melanocortin receptors. By enabling comparative studies of structure-activity relationships, it assists in the rational design and optimization of next-generation peptide ligands for research applications.
1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
5. TMEM16F and dynamins control expansive plasma membrane reservoirs
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