Melanostatin DM is an inhibitor of α-melanocyte stimulating hormone (α-MSH), which is the primary hormone that controls production of melanin pigment.
CAT No: 10-101-221
CAS No:123689-72-5
Synonyms/Alias:Haatpln;123689-72-5;H-His-D-arg-ala-trp-D-phe-lys-NH2;Histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide;(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide;L-Lysinamide, L-histidyl-D-arginyl-L-alanyl-L-tryptophyl-D-phenylalanyl-;DTXSID00924570;(2S)-6-amino-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-5-carbamimidamidopentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanamido]hexanamide;(S)-2-((6R,9S,12S,15R)-12-((1H-indol-3-yl)methyl)-1-amino-6-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-15-benzyl-1-imino-9-methyl-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-amido)-6-aminohexanamide;1-Amino-18-(4-aminobutyl)-6-{[2-amino-1-hydroxy-3-(1H-imidazol-5-yl)propylidene]amino}-15-benzyl-7,10,13,16-tetrahydroxy-1-imino-12-[(1H-indol-3-yl)methyl]-9-methyl-2,8,11,14,17-pentaazanonadeca-7,10,13,16-tetraen-19-imidic acid;
Melanostatin DM, also known as Melanocyte-Inhibiting Factor or MIF, is a synthetic peptide that functions as a potent antagonist of alpha-melanocyte-stimulating hormone (α-MSH). This compound is recognized for its ability to modulate melanogenesis by interfering with the signaling pathways that regulate melanin synthesis in melanocytes. Melanostatin DM exhibits high specificity for its target, enabling precise experimental manipulation of pigmentation processes in vitro and in vivo. As such, it has become a valuable research tool in the fields of dermatology, pigment cell biology, and cosmetic science, allowing investigators to dissect the molecular mechanisms underlying skin color regulation and pigmentation disorders. Its stability and compatibility with a variety of biological systems further support its widespread adoption in laboratory protocols focused on cellular signaling and pigmentary control.
Pigmentation Research: Melanostatin DM is widely utilized in pigmentation research to elucidate the cellular and molecular mechanisms of melanin production. By antagonizing α-MSH at the melanocortin 1 receptor (MC1R), it provides researchers with a reliable method to downregulate melanin synthesis in cultured melanocytes or skin models. This capability is instrumental in studying hyperpigmentation, hypopigmentation, and the dynamic regulation of skin color in response to environmental factors such as UV exposure. The peptide's selective inhibition of melanogenesis enables the development of controlled experimental systems for evaluating novel depigmenting agents and understanding the physiological role of MC1R signaling in skin biology.
Cosmetic Science: In the development of cosmetic formulations aimed at skin tone modulation, Melanocyte-Inhibiting Factor serves as a reference compound for screening and benchmarking the efficacy of skin-lightening ingredients. Its mechanism of action, which involves the competitive inhibition of α-MSH binding to MC1R, allows for precise assessment of depigmenting effects in reconstructed skin models or ex vivo tissue assays. Cosmetic scientists employ it to validate the performance of new compounds designed to reduce hyperpigmentation, providing a scientific foundation for claims related to even skin tone and radiance. Additionally, it aids in the design of safer and more targeted cosmetic products by offering insights into the molecular pathways affected by active ingredients.
Cell Signaling Studies: Researchers investigating the broader aspects of G-protein-coupled receptor (GPCR) signaling frequently incorporate Melanostatin DM into their experimental toolkits. By modulating the activity of MC1R, a prototypical GPCR, it enables the dissection of downstream signaling cascades such as cyclic AMP (cAMP) production and protein kinase A (PKA) activation. These studies contribute to a better understanding of how extracellular signals are transduced into cellular responses, with implications for diverse biological processes beyond pigmentation. The peptide's well-characterized antagonistic properties make it a model compound for exploring receptor-ligand interactions and signal transduction mechanisms in various cell types.
Neuroendocrinology Research: Melanostatin DM is also employed in neuroendocrinology to investigate the regulatory role of melanocortins in the central nervous system. By blocking α-MSH activity, it facilitates studies on hypothalamic pathways involved in appetite control, energy homeostasis, and stress responses. Researchers use it to probe the physiological significance of melanocortin signaling in neuronal circuits, advancing knowledge of how peptide hormones influence neurobiological functions. Its application in this context supports the identification of novel targets for modulating neuroendocrine processes and understanding the interplay between pigmentation and brain function.
Comparative Biology: In comparative studies, Melanocyte-Inhibiting Factor is leveraged to explore evolutionary differences in pigmentation mechanisms across species. By applying it to pigment cells derived from various organisms, scientists can assess the conservation or divergence of melanocortin pathways and their impact on phenotypic variation. These investigations shed light on the adaptive significance of pigmentation traits in response to ecological pressures, contributing to evolutionary biology and genetics research. The ability to manipulate melanin synthesis with a specific antagonist like Melanostatin DM enables cross-species comparisons that deepen our understanding of pigmentary evolution and diversity.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More