Melittin

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#R1513
Chemical Structure
ExplanationMelittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
Synonyms/AliasHoneybee melittin; Bee venom melittin; Forapin
M.F/FormulaC₁₃₁H₂₂₉N₃₉O₃₁
M.W/Mr.2846.46
SequenceOne Letter Code: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
three Letter Code: Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Biological ActivityInhibits Gs and stimulates Gi activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na+/K+ ATPase inhibitor.
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