α-Methyl-L-tyrosine is a non-proteinogenic, α-methylated derivative of the aromatic amino acid tyrosine, featuring a phenolic side chain and an extra methyl substituent at the α-carbon that differentiates it from unmodified tyrosine. The molecule contains a free amino group and a free carboxyl group along with an L-configuration at the α-stereocenter indicated by the name, and the phenolic hydroxyl on the aromatic ring provides a hydrogen-bonding and potential derivatization handle for conjugation or further functionalization. In peptide and protein chemistry, α-methyl substitution at the backbone position is commonly used in structure-activity and structure-property studies to probe effects on peptide conformation and proteolytic stability, and the aromatic phenol can be used to support analytical labeling or chemical modification strategies.
CAT No: CP18901
CAS No:672-87-7
Synonyms/Alias:METYROSINE;Metirosine;alpha-Methyl-L-tyrosine;alpha-Methyltyrosine;(S)-alpha-Methyltyrosine;672-87-7;Methyltyrosine;Demser;L-alpha-Methyl-p-tyrosine;Metirosinum;Metirosina;Alpha-Methyl-L-P-Tyrosine;L-alpha-Methyltyrosine;L-AMPT;L-Metyrosine;(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoicacid;L(-)-Metyrosine;Metirosine(INN);Metyrosine(USP);(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoicacid;Demser(TN);AmbotzHAA5490;a-methyl-L-p-tyrosine;Spectrum3_001846;UNII-DOQ0J0TPF7
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