NH2-UAMC1110 is a peptide-inspired scaffold with defined aromatic and polar features that support targeted binding. Researchers explore its structure using spectroscopic tools to characterize conformational equilibria. Applications include ligand screening, PPI modeling, and SAR evaluation.
CAT No: R2819
Synonyms/Alias:NH2-UAMC1110; 2758337-19-6; UAMC1110-NH2; SCHEMBL23531732; UAMC1110-NH2?; EX-A7847R; HY-153552; CS-0783398; (S)-6-(4-Aminobutoxy)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide; 6-(4-aminobutoxy)-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
NH2-UAMC1110, a synthetic carbohydrate compound, is recognized for its unique structural properties and versatile reactivity, making it a valuable tool in advanced biochemical research and molecular development projects. As a derivative featuring an amino group and specialized carbohydrate backbone, NH2-UAMC1110 offers enhanced solubility and compatibility with a wide range of laboratory protocols. Its design supports targeted conjugation, labeling, and modification, allowing researchers to explore complex biological systems with improved specificity and efficiency. The compound's stability under physiological conditions and its amenability to various chemical transformations have positioned it as a preferred choice for those investigating carbohydrate-mediated interactions and pathways. NH2-UAMC1110's adaptability across multiple scientific disciplines underlines its importance in both foundational and applied research settings.
Glycobiology Research: In the field of glycobiology, NH2-UAMC1110 serves as a critical reagent for probing glycan structures and studying carbohydrate-protein interactions. Researchers employ this compound to synthesize glycomimetics and to map the roles of specific carbohydrate motifs in cellular signaling, recognition, and immune responses. Its amino functional group facilitates site-specific attachment to biomolecules, enabling the creation of tailored probes and affinity tags that advance the understanding of glycan-mediated biological processes.
Bioorthogonal Labeling: NH2-UAMC1110 is frequently utilized in bioorthogonal labeling strategies, where its reactive amino group allows for selective conjugation with various reporter molecules, such as fluorescent dyes or biotin. This application is pivotal in visualizing and tracking biomolecules within complex biological systems, as the compound can be incorporated into glycoproteins or other macromolecules without perturbing native cellular functions. The resulting labeled entities are instrumental in real-time imaging, localization studies, and quantitative analyses in live-cell or in vitro environments.
Drug Discovery and Development: Within drug discovery pipelines, UAMC1110 derivatives are explored as scaffolds for the design of novel therapeutic candidates, particularly in the context of carbohydrate-based drug development. Its structure is conducive to the generation of libraries of analogs with diverse functional groups, supporting high-throughput screening for bioactivity and target engagement. The compound's compatibility with combinatorial chemistry techniques accelerates the identification of lead compounds that modulate carbohydrate-recognizing enzymes or receptors, thus expanding the repertoire of potential drug candidates.
Enzyme Substrate and Inhibitor Studies: The compound is also employed as a substrate or inhibitor analog in enzymatic assays to elucidate the mechanisms of carbohydrate-processing enzymes. By incorporating NH2-UAMC1110 into assay systems, scientists can dissect enzyme specificity, kinetics, and inhibition profiles, which are essential for understanding metabolic pathways and for the rational design of enzyme modulators. Its defined structure and functional group accessibility make it an ideal candidate for kinetic studies and mechanistic investigations.
Material Science and Surface Engineering: In material science, NH2-UAMC1110 is leveraged for the functionalization of surfaces and the development of carbohydrate-based coatings. Its reactive amino group allows for stable covalent attachment to various substrates, facilitating the fabrication of bioactive surfaces that mimic natural glycan presentations. These engineered materials find applications in biosensors, tissue engineering scaffolds, and diagnostic platforms, where controlled carbohydrate display is crucial for specific molecular recognition events.
Synthetic carbohydrate compounds such as NH2-UAMC1110 continue to fuel innovation across scientific disciplines, providing researchers with powerful tools to dissect and manipulate carbohydrate-related phenomena. Its multifaceted applications in glycobiology, chemical biology, drug discovery, enzymology, and material science exemplify its central role in advancing both fundamental research and technological development. As new methodologies and research questions emerge, the versatility and reliability of NH2-UAMC1110 ensure its ongoing relevance and utility in the expanding landscape of carbohydrate chemistry and its interdisciplinary intersections.
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