Exhibiting tremendous inhibitory effects on cyclophilin D, NIM811 emerges as a highly potent and sought-after agent within the biomedical sector. Its application is not limited to a single disease; rather, it encompasses the potential research of a plethora of maladies ranging from hepatitis C to dengue fever and even neurodegenerative disorders. This compound showcases remarkable pharmacological attributes, thus rendering NIM811 an indispensable component of diverse drug discovery initiatives aiming for therapeutic advancements.
CAT No: R1972
CAS No:143205-42-9
Chemical Name:(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-24-[(2S)-butan-2-yl]-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18-tris(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
NIM811 is a non-immunosuppressive cyclosporin A analog recognized for its potent inhibition of mitochondrial permeability transition pore (mPTP) opening. Structurally derived from the cyclosporin family, NIM811 retains high affinity for cyclophilin D but lacks the immunosuppressive properties typically associated with its parent compound. This unique biochemical profile has made it a valuable research tool for dissecting mitochondrial function, studying cell death pathways, and exploring mechanisms of organelle protection under stress. Its selective action on mitochondrial targets provides an important advantage for experimental systems where immune modulation is undesirable, enabling more precise interrogation of mitochondrial physiology and pathology.
Mitochondrial permeability transition research: NIM811 serves as a critical probe in studies focused on the regulation of the mitochondrial permeability transition pore. By inhibiting mPTP opening, it enables researchers to investigate the role of mitochondrial membrane potential, calcium overload, and oxidative stress in cell death and survival. Its use has been instrumental in clarifying how mitochondrial integrity is maintained under pathological conditions such as ischemia-reperfusion injury and neurodegenerative stress, offering insights into the fundamental processes governing cellular fate.
Cell death and apoptosis studies: The compound is widely utilized in experimental models to distinguish between necrotic and apoptotic cell death mechanisms. Its ability to selectively block mPTP-mediated necrosis without affecting cyclosporin A's immunosuppressive pathways allows for refined analysis of mitochondrial-driven cell death. Researchers employ NIM811 to dissect the contributions of mitochondrial dysfunction in apoptosis, providing a clearer understanding of the interplay between energy metabolism, reactive oxygen species production, and programmed cell death signaling.
Organ and tissue injury modeling: In models of acute organ damage, such as cardiac, hepatic, or neural injury, NIM811 is frequently applied to assess the protective effects of mPTP inhibition. Its use supports the evaluation of mitochondrial-targeted interventions and helps delineate the contribution of mitochondrial permeability to tissue viability following stress. Through these applications, it aids in the identification of molecular targets for cytoprotection and the development of strategies to mitigate cellular injury in translational research settings.
Drug discovery and screening: The compound is a valuable tool in high-throughput screening platforms aimed at identifying novel modulators of mitochondrial function. Its defined mechanism of action and lack of immunosuppressive activity make it suitable for differentiating off-target effects of candidate molecules on the mPTP. Utilization of NIM811 in these assays enhances the specificity of screening protocols, supporting the discovery of new chemical entities that target mitochondrial pathways without confounding immune-related artifacts.
Mitochondrial physiology and bioenergetics analysis: Researchers employ NIM811 to investigate the dynamics of mitochondrial respiration, ATP synthesis, and calcium handling in isolated organelles, cell lines, and tissue preparations. By modulating the permeability transition pore, it provides a controlled experimental context for studying the links between mitochondrial bioenergetics, calcium homeostasis, and cellular stress responses. These studies contribute to a deeper understanding of mitochondrial biology and the factors influencing organelle function under both physiological and pathological conditions.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More