Palmitoyl tripeptide-8

Palmitoyl tripeptide-8 is a synthetic peptide composed of three amino acids conjugated with a palmitoyl chain to enhance skin affinity and stability. Widely utilized in cosmetic formulations, it is valued for its role in supporting skin comfort and helping to maintain a balanced appearance, particularly in products designed for sensitive or reactive skin. Its compatibility with various formulation types makes it suitable for use in a broad range of skincare applications.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Palmitoyl tripeptide-8(CAS 936544-53-5)

CAT No: CPC1653

CAS No:936544-53-5

Synonyms/Alias:Palmitoyl tripeptide-8;936544-53-5;55HZC7YQA7;RE053;UNII-55HZC7YQA7;Palmitoyl tripeptide-8 [INCI];N-(1-Oxohexadecyl)-L-histidyl-D-phenylalanyl-L-argininamide;L-Argininamide, N-(1-oxohexadecyl)-L-histidyl-D-phenylalanyl-;N-[(2S)-1-[[(2R)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]hexadecanamide;Palmitoyl Tripeptide-8?;Pal-His-D-Phe-Ala-NH2;WBHUVOTYPRYBNG-QAXCHELISA-N;HY-P5226;DA-66464;CS-0863735;D92814;

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cGMP Peptide
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  • CMC information required for an IND
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  • Drug master files (DMF) filing
M.F/Formula
C37H61N9O4
M.W/Mr.
695.9
Sequence
One Letter Code:HFR
Three Letter Code:palmitoyl-His-D-Phe-Arg-NH2
Application
Anti-inflammatory
Appearance
White powder

Mechanism of Action (MOA)

Palmitoyl tripeptide-8 is a biomimetic signaling peptide composed of three amino acids conjugated to a palmitic acid moiety for enhanced skin affinity. It is designed to interact with key cellular pathways involved in skin homeostasis. By modulating the activity of neurogenic mediators and supporting balanced intercellular communication, palmitoyl tripeptide-8 helps maintain optimal skin barrier function and contributes to a harmonious cellular environment.

Palmitoyl tripeptide-8 is a versatile peptide suitable for incorporation into various cosmetic formulations.

- Facial serums for daily skincare routines
- Moisturizing creams and lotions
- Soothing gel masks and leave-on treatments
- After-sun and post-procedure products
- Sensitive skin formulations
- Eye contour creams and gels

InChI
InChI=1S/C37H61N9O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-22-33(47)44-32(25-29-26-41-27-43-29)36(50)46-31(24-28-19-15-14-16-20-28)35(49)45-30(34(38)48)21-18-23-42-37(39)40/h14-16,19-20,26-27,30-32H,2-13,17-18,21-25H2,1H3,(H2,38,48)(H,41,43)(H,44,47)(H,45,49)(H,46,50)(H4,39,40,42)/t30-,31+,32-/m0/s1
InChI Key
WBHUVOTYPRYBNG-QAXCHELISA-N

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