Pancreatic Polypeptide Therapy (PPT) revolutionizes the medical landscape by harnessing the formidable power of bioengineering. This scientific breakthrough brings forth promising prospects in the realm of pancreatic afflictions. Hypothesized to rectify pancreatic maladies, PPT intricately orchestrates the regulation of satiety, digestive fluid secretion, and glucose regulation.
CAT No: R2080
CAS No:59763-91-6
Chemical Name:(4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
Pancreatic polypeptide is a naturally occurring peptide hormone composed of 36 amino acid residues, predominantly produced by the F cells of the pancreatic islets. As a member of the neuropeptide Y (NPY) family, it plays a significant role in regulating pancreatic secretion activities, gastrointestinal motility, and energy homeostasis. Its unique sequence and structural features have made it a subject of considerable interest in both fundamental and applied biochemical research, especially concerning the endocrine and metabolic functions of the pancreas. The peptide's involvement in complex signaling pathways and its cross-talk with other regulatory peptides underscore its value as a tool for dissecting hormone-mediated physiological processes.
Peptide functional studies: Pancreatic polypeptide serves as a crucial probe in elucidating the regulatory mechanisms underlying endocrine and exocrine pancreatic functions. Researchers utilize it to investigate receptor-mediated signaling pathways, particularly those involving Y-family G protein-coupled receptors expressed in pancreatic and gastrointestinal tissues. By studying its interactions with these receptors, scientists gain deeper insights into the modulation of digestive enzyme secretion, appetite regulation, and energy balance, thereby advancing the broader understanding of peptide hormone function in metabolic networks.
Receptor binding assays: The peptide's high specificity for pancreatic polypeptide receptors makes it an indispensable ligand in receptor binding and characterization studies. It is commonly used to quantify receptor density, affinity, and distribution in various tissue preparations, supporting the identification of novel receptor subtypes and the mapping of their physiological roles. These assays are foundational for pharmacological profiling and for the development of selective receptor modulators in experimental research settings.
Peptide synthesis and analog development: Pancreatic polypeptide acts as a reference template in the design and synthesis of peptide analogs with modified stability or receptor selectivity. Synthetic chemists and peptide technologists employ it to benchmark the activity and structural integrity of analogs intended for mechanistic studies or as molecular probes. This application is vital for structure-activity relationship investigations, enabling the rational optimization of peptide-based tools for advanced research applications.
Metabolic research models: In metabolic physiology, the peptide is used to model the regulation of food intake, glucose homeostasis, and energy expenditure in both in vitro and in vivo systems. Its administration in experimental protocols helps delineate the cross-regulation between pancreatic hormones and their impact on systemic metabolic states. Such studies are instrumental in unraveling the complex feedback loops that govern nutrient sensing and energy distribution at the organismal level.
Analytical assay development: Pancreatic polypeptide is frequently employed as a standard or calibrator in immunoassays, chromatographic methods, and mass spectrometry-based quantitation techniques. Its defined structure and immunogenic properties facilitate the validation and optimization of sensitive detection platforms for peptide hormones in biological samples. This application supports the accurate measurement of peptide levels in experimental studies, contributing to robust data generation and reproducibility in biochemical research.
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