Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4.
Pancreatic Polypeptide, rat is a synthetic peptide corresponding to the naturally occurring pancreatic polypeptide found in Rattus norvegicus. As a member of the neuropeptide Y (NPY) family, it plays a significant role in the regulation of pancreatic secretion, gastrointestinal motility, and energy homeostasis in rodents. Its unique sequence and receptor specificity make it a valuable molecular tool for investigating mechanisms of peptide hormone action, receptor pharmacology, and neuroendocrine signaling. The compound's relevance extends to studies of metabolic regulation, appetite control, and the neurochemical pathways underlying digestive processes, positioning it as a critical reagent in preclinical biochemical and physiological research.
Peptide receptor characterization: Pancreatic polypeptide from rat is widely utilized in the characterization of peptide receptors, particularly Y-family G protein-coupled receptors such as Y4 and Y5 subtypes. By employing the peptide in binding assays, signal transduction studies, or receptor mapping experiments, researchers can delineate receptor selectivity, ligand affinity, and downstream signaling pathways. These insights are essential for understanding peptide-receptor interactions, informing the development of receptor-specific agonists or antagonists, and elucidating the physiological roles of these receptors in the rodent pancreas and central nervous system.
Metabolic regulation research: The peptide serves as an important tool for probing the mechanisms underlying energy balance and glucose homeostasis. Experimental administration of rat pancreatic polypeptide in cell-based assays or animal models enables detailed studies of its effects on insulin secretion, glucagon release, and hepatic glucose production. Such work helps clarify the peptide's contribution to the neuroendocrine regulation of metabolism, supporting investigations into the molecular basis of metabolic disorders and the complex interplay between gut-derived hormones and systemic energy management.
Appetite and feeding behavior studies: Researchers employ rat pancreatic polypeptide to investigate its influence on appetite regulation and satiety signaling within the hypothalamus and related neural circuits. By examining the peptide's effects on food intake, meal patterns, and neuronal activation, scientists gain valuable information about the neurochemical pathways involved in feeding behavior. These studies are instrumental in advancing the understanding of how peripheral signals modulate central appetite control mechanisms in rodent models.
Gastrointestinal physiology investigations: The compound is frequently used to explore its modulatory effects on gastrointestinal motility, exocrine pancreatic secretion, and gastric emptying. Through in vitro and in vivo experiments, the peptide facilitates the dissection of its role in the regulation of digestive processes, providing a basis for understanding the physiological integration of the gut-brain axis. Such research is critical for mapping the feedback mechanisms that coordinate nutrient intake, digestion, and energy utilization in rodents.
Peptide structure-function analysis: Pancreatic polypeptide from rat is also employed in studies focused on elucidating the relationship between peptide structure and biological activity. By synthesizing analogs, performing site-directed mutagenesis, or conducting NMR and crystallography analyses, researchers can identify key residues responsible for receptor binding, signal transduction, and stability. These investigations not only deepen knowledge of peptide hormone biochemistry but also support the rational design of novel peptide-based probes and modulators for advanced research applications.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
2. Implications of ligand-receptor binding kinetics on GLP-1R signalling
4. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
5. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More