PE22-28 is a synthetic derivative of the naturally occurring peptide spadin.
CAT No: 10-101-312
CAS No:1801959-12-5
Synonyms/Alias:PE 22-28;1801959-12-5;EX-A8193F;HY-P3581;L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-;DA-66537;CS-0615995;(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid;
PE22-28 is a synthetic peptide derived from the neurotrophic protein spadin, recognized for its selective modulation of the TREK-1 potassium channel. As a research-grade peptide, PE22-28 has garnered significant attention in neurobiology due to its ability to influence neuronal excitability and synaptic transmission. Its unique sequence and functional properties make it a valuable molecular tool for elucidating ion channel dynamics, exploring neuroprotective mechanisms, and investigating the biochemical pathways underlying neural plasticity. The compound's specificity and stability further enhance its suitability for a wide range of experimental applications within the neurosciences and related fields.
Ion Channel Research: One of the primary applications of PE22-28 lies in the targeted study of two-pore domain potassium channels, particularly TREK-1. By acting as a selective modulator, the peptide enables researchers to dissect the physiological and pharmacological roles of TREK-1 in neuronal cells. Its use allows for precise investigations into how potassium channel activity contributes to membrane potential regulation, neuronal firing patterns, and overall neural circuit function. Such studies are pivotal for advancing the understanding of ion channelopathies and the broader landscape of neuronal signaling.
Neuropharmacology Studies: PE22-28 serves as an important tool in neuropharmacological research, where it is employed to probe the mechanisms of action of compounds affecting neurotrophic signaling. The peptide's interaction with TREK-1 provides a controlled system for evaluating the downstream effects of channel modulation on neurotransmitter release, synaptic plasticity, and neuroprotection. By incorporating this peptide into experimental protocols, scientists can obtain mechanistic insights into the modulation of neural networks and identify potential molecular targets for further investigation.
Electrophysiological Assays: The compound is extensively utilized in electrophysiological experiments to characterize the functional properties of potassium channels in vitro. Application of PE22-28 to cultured neurons or heterologous expression systems enables the measurement of changes in ion currents and membrane conductance. These assays are fundamental for quantifying channel kinetics, assessing pharmacological sensitivity, and validating the specificity of channel modulators. The reproducibility and reliability of such data are critical for both basic research and the development of novel neuroactive agents.
Peptide Structure-Activity Relationship (SAR) Analysis: Researchers leverage PE22-28 in structure-activity relationship studies to delineate the key amino acid residues responsible for channel binding and modulation. By systematically modifying the peptide sequence and assessing functional outcomes, investigators can map the interaction domains critical for activity. These findings not only inform the rational design of next-generation peptide modulators but also enhance the broader understanding of peptide-protein interactions in neurobiology.
Neuroprotective Mechanism Exploration: The selective action of PE22-28 on neuronal potassium channels makes it an effective probe for exploring endogenous neuroprotective pathways. In models of neuronal stress or injury, the peptide can be used to investigate how modulation of TREK-1 influences cell survival, apoptosis, and adaptive responses. Such studies contribute to the foundational knowledge required for developing strategies aimed at preserving neuronal function under pathological conditions, without extending into clinical or therapeutic claims.
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