Pentapeptide-18 (Leuphasyl) is a synthetic peptide composed of five amino acids designed for use in topical cosmetic formulations. It is recognized for its ability to support the appearance of smoother skin by targeting expression lines. Suitable for a variety of skin care applications, Pentapeptide-18 is compatible with standard cosmetic ingredients and can be incorporated into serums, creams, and emulsions intended for mature or age-related skin concerns.
CAT No: HB00127
CAS No:64963-01-5
Synonyms/Alias:64963-01-5;[D-Ala2]leucine-enkephalin;Leuphasyl;Tyr-D-Ala-Gly-Phe-Leu;Pentapeptide-18;(D-Ala2)-Leu-Enkephalin;(D-Ala2)leucine-enkephalin;H-Tyr-D-Ala-Gly-Phe-Leu-OH;L-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-;PO4D55T1IG;[D-Ala2]-Leu-Enkephalin;L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine;(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid;DALLE;(D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH;NSC-374895;EINECS 265-291-0;MFCD00076409;NSC 374895;UNII-PO4D55T1IG;CHEMBL4539258;SCHEMBL11396067;BDBM82090;ZHUJMSMQIPIPTF-JMBSJVKXSA-N;1-5-(D-ALA2)-DYNORPHIN;HY-P0098;N-(N-(N-(N-L-Tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucine;AKOS030529562;CS-5905;AC-31944;AS-76027;DA-69132;FA108766;NS00055427;C76035;H-Tyr-D-Ala-Gly-Phe-Leu-OH; H-Y(dA)GFL-OH;L-leucine, N-(N-(N-(N-L-Tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-;(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid;(2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid;
Mechanism of Action (MOA)
Pentapeptide-18 (Leuphasyl) is a synthetic signal peptide designed to interact with neuronal communication pathways in the skin. By mimicking a natural enkephalin sequence, it can modulate the release of neurotransmitters involved in facial muscle contraction. This peptide is thought to influence the SNARE complex assembly, supporting a balanced neuronal signaling environment. Its activity is associated with the regulation of skin's response to repetitive facial movements, contributing to a smoother appearance.
Pentapeptide-18 (Leuphasyl) is suitable for incorporation into various cosmetic formulations targeting facial care.
- Serums designed for daily skin maintenance routines- Moisturizing creams and lotions for facial application- Eye contour products such as gels or creams- Sheet masks and leave-on treatments- Makeup primers with added skincare benefits- Night care products for regular use
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