Peripheral Myelin P0 Protein (180-199), mouse, a neuritogenic peptide, is a purified component of murine peripheral nerve myelin.
CAT No: R1931
CAS No:147450-30-4
Synonyms/Alias:Peripheral Myelin P0 Protein (180-199), mouse;147450-30-4;AKOS040756845;DA-56699;
Peripheral Myelin P0 Protein (180-199), mouse, is a synthetic peptide fragment derived from the amino acid sequence of the mouse peripheral myelin protein zero (P0), specifically encompassing residues 180 to 199. As a major structural component of peripheral nerve myelin, P0 plays a crucial role in myelin sheath formation and maintenance, mediating homophilic adhesion and contributing to the structural integrity of myelinated fibers. The 180-199 region of P0 is of particular interest due to its immunodominant properties and relevance in experimental models of autoimmune neuropathies. Researchers utilize this peptide to investigate the molecular mechanisms underlying peripheral nerve biology, myelin-associated autoimmune responses, and protein-protein interactions within the nervous system.
Autoimmunity Research: Use of the P0 (180-199) peptide is well-established in the study of autoimmune neuropathies, particularly experimental autoimmune neuritis (EAN), an animal model that mimics aspects of human demyelinating diseases such as Guillain-Barré syndrome. By serving as an immunogen, the peptide enables the induction and analysis of T cell-mediated immune responses against peripheral myelin antigens. This approach provides valuable insights into the pathogenesis of inflammatory demyelination, the identification of pathogenic epitopes, and the evaluation of immunomodulatory interventions in preclinical settings.
Epitope Mapping: The defined sequence of the 180-199 segment allows for precise epitope mapping studies, facilitating the identification of T cell and B cell recognition sites within the P0 protein. Such mapping is critical for understanding the fine specificity of immune responses in peripheral nerve disorders and for dissecting the molecular determinants of antigenicity. The peptide serves as a powerful tool in delineating the immunological landscape of myelin proteins and in guiding the design of targeted immunological assays.
T Cell Activation Assays: In vitro stimulation of lymphocytes with the P0 (180-199) peptide supports detailed analysis of antigen-specific T cell activation, proliferation, and cytokine secretion. Researchers employ this peptide in cellular assays to characterize the functional profile of autoreactive T cells, assess antigen presentation pathways, and investigate mechanisms of immune tolerance or breakdown. These studies are instrumental in unraveling the cellular dynamics that drive peripheral nerve inflammation and demyelination.
Antibody Detection: The peptide is frequently utilized in immunological assays such as ELISA or immunoblotting to detect and quantify antibodies directed against P0 epitopes in experimental models. This application aids in monitoring humoral immune responses during disease progression or therapeutic intervention, and in characterizing the serological features of autoimmune neuropathies. By providing a defined target, the peptide enhances the specificity and reliability of antibody detection protocols.
Protein-Ligand Interaction Studies: The 180-199 fragment of P0 is also employed in biophysical and biochemical assays to examine protein-ligand interactions relevant to myelin biology. These studies may include binding analyses with antibodies, cell surface receptors, or other myelin-associated molecules, contributing to a deeper understanding of molecular recognition events in peripheral nerve tissue. The peptide's defined structure and sequence specificity make it an ideal probe for dissecting interaction networks within the myelin microenvironment.
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