PHI 27 features a peptide motif with balanced hydrophobic, polar, and basic residues that influence folding and solubility. Structural flexibility supports studies of receptor interaction and signaling mechanisms. Researchers analyze its domain-level transitions and hydrogen-bonding patterns. Applications span bioactive peptide modeling, structural research, and sequence-function mapping.
CAT No: R2334
CAS No:80458-29-3
Synonyms/Alias:80458-29-3;CID 16132346;PHI 27;L-Isolecucinamide, L-histidyl-L-alanyl-L-alpha-aspartylglycyl-L-valyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-phenylalanyl-L-seryl-L-arginyl-L-leucyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-glutamyl-L-seryl-L-leucyl-;FP73565;NCGC00167207-01;
PHI 27, also known as Peptide Histidine Isoleucine 27, is a naturally occurring neuropeptide derived from the preprovasoactive intestinal peptide (preproVIP) precursor. Characterized by its unique amino acid sequence and structural stability, PHI 27 is widely recognized for its significant role in modulating gastrointestinal, endocrine, and nervous system activities. Researchers value this peptide for its multifaceted biological functions and its ability to interact with specific G protein-coupled receptors, which makes it a powerful tool for investigating complex physiological pathways. Its high solubility and compatibility with various assay systems further enhance its utility in experimental settings, making it a preferred choice for in-depth scientific studies across multiple disciplines.
Neurobiology research: PHI 27 serves as an essential molecular probe in neurobiology, enabling researchers to study the regulation of neuronal signaling and synaptic transmission. By interacting with specific receptors in the central and peripheral nervous systems, this peptide helps elucidate the mechanisms underlying neurotransmitter release, neuronal excitability, and plasticity. Its application in in vitro and in vivo models allows for the dissection of neural circuits and the investigation of neuropeptide-mediated modulation of behavior and cognition. Through these studies, scientists gain new insights into the role of regulatory peptides in brain function and neural communication.
Gastrointestinal physiology: In gastrointestinal research, PHI 27 is utilized to explore the modulation of intestinal motility, secretion, and absorption. Researchers employ this peptide to investigate how neuropeptides influence the enteric nervous system, smooth muscle contraction, and the regulation of digestive enzymes. By applying PHI 27 in organ bath experiments, tissue cultures, or animal models, scientists can delineate its effects on gut physiology, such as its ability to relax intestinal smooth muscle or modulate secretory processes. These findings contribute to a more comprehensive understanding of peptide-mediated control of digestive function and the intricate communication between the gut and the nervous system.
Endocrine signaling studies: PHI 27 is instrumental in the study of hormone secretion and endocrine regulation. Its interactions with pancreatic cells, pituitary tissue, and other endocrine organs provide a valuable framework for investigating the role of neuropeptides in hormone release and feedback mechanisms. Researchers use this peptide to modulate the secretion of key hormones, thereby unraveling the signaling pathways and intracellular cascades involved in endocrine homeostasis. These experimental approaches help clarify the complex interplay between neuropeptides and hormonal control, with implications for understanding metabolic regulation and stress responses.
Receptor pharmacology: Scientists employ PHI 27 to characterize and differentiate G protein-coupled receptor subtypes and their downstream signaling pathways. Through binding assays, functional analyses, and receptor mapping, this peptide aids in identifying specific receptor targets and elucidating their physiological relevance. By using PHI 27 as a ligand in competitive binding or activation studies, researchers can assess receptor affinity, signal transduction mechanisms, and the selectivity of novel pharmacological agents. These studies are fundamental for advancing receptor pharmacology and for the development of new molecular tools targeting neuropeptide receptors.
Peptide structure-function analysis: In structural biology and peptide chemistry, PHI 27 is used to investigate the relationship between peptide sequence, conformation, and biological activity. Through techniques such as nuclear magnetic resonance (NMR) spectroscopy, circular dichroism, and mutagenesis, researchers analyze how specific amino acid residues contribute to receptor binding and functional outcomes. This peptide serves as a model for studying the design of synthetic analogs and the optimization of peptide-based probes. These efforts expand the knowledge of peptide-receptor interactions and support the rational development of novel bioactive peptides for research applications.
PHI 27 continues to be a versatile and indispensable tool in scientific research, offering valuable insights into neurobiology, gastrointestinal physiology, endocrine signaling, receptor pharmacology, and peptide structure-function relationships. Its multifaceted applications enable researchers to unravel complex biological processes, develop innovative experimental approaches, and advance the understanding of peptide-mediated regulation in diverse physiological systems. As research into neuropeptides and their receptors progresses, PHI 27 remains at the forefront, providing a foundation for future discoveries and the refinement of molecular research techniques.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More