Phosphoramidon

Phosphoramidon is a neutral endopeptidase 24.11 (NEP, neprilysin; EC 3.4.24.11) (Ki=2nM) inhibitor, which cleaves bioactive peptides such as bradykinin, neurotensin, and enkephalin. It also inhibits neprilysin 2 (Ki~2nM) and endothelin-converting enzyme (ECE) (IC50=0.68 μM).

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CAT#R0805
CAS119942-99-3
Synonyms/AliasN-(alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan
M.F/FormulaC23H32N3Na2O10P
M.W/Mr.587.50
Labeling TargetMetallo-endopeptidase
ApplicationMetallo-endopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Inhibits thermolysin, membrane metallo-endopeptidases, and endothelin converting enzyme. Also inhibits NEP 24.11 and NEP2 and weakly inhibits collegenase.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityInhibitor
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