Prezatide copper acetate is a complex composed of tripeptide prezatide, acetic acid and copper ion. Prezatide is used for skin care, and has the potential to treat chronic obstructive pulmonary disease and metastatic colon cancer.
CAT No: R1966
CAS No:130120-57-9
Synonyms/Alias:130120-57-9;Iamin; PC 1020 acetate;Prezatide copper acetate;Cuprate(1-), (glycyl-L-histidyl-kappaN1-L-lysinato)[glycyl-kappaN-L-histidyl-kappaN,kappaN3-L-lysinato(2-)]-, hydrogen, acetate (1:1:2);copper(2+) bis(acetic acid) bis(6-amino-2-[2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido]hexanoate);copper,acetic acid,(2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid;copper;acetic acid;6-amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate;
Chemical Name:copper;acetic acid;(2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
Prezatide Copper Acetate is a synthetic peptide-metal complex that combines a bioactive peptide sequence with copper ions, conferring unique biochemical properties relevant to peptide research and metallopeptide studies. As a member of the copper peptide family, it is characterized by its ability to mimic certain endogenous peptide-metal interactions, making it an important tool for investigating peptide-metal coordination chemistry, biological signaling, and cellular processes influenced by metal ions. Its distinct structure and reactivity have positioned it as a valuable compound for academic, industrial, and pharmaceutical research environments focused on peptide functionality and metalloprotein analogs.
Peptide-Metal Interaction Studies: Prezatide Copper Acetate is widely utilized in the exploration of peptide-metal binding mechanisms, enabling researchers to model and analyze the coordination behavior of peptides with transition metals. Through controlled in vitro experiments, it serves as a model system for elucidating how copper ions influence peptide conformation, stability, and reactivity, shedding light on fundamental aspects of metalloprotein structure and function. Such studies are critical for understanding the biochemical principles underlying metallopeptide activity in both natural and synthetic systems.
Enzymatic Activity Modulation: The compound's unique structure allows it to function as a tool for probing the modulation of enzymatic processes that are dependent on copper ions. In particular, Prezatide Copper Acetate has been employed to investigate the activation or inhibition of copper-dependent enzymes, such as oxidases and hydrolases, by serving as a substrate analog or competitive ligand. By examining its effects on enzyme kinetics and catalysis, researchers can gain insights into the mechanistic roles of copper-peptide complexes in biological oxidation-reduction reactions.
Peptide Synthesis and Functionalization: In peptide chemistry, Prezatide Copper Acetate is valuable for the synthesis and post-synthetic modification of peptides that require site-specific metal incorporation. Its defined peptide-copper structure facilitates the preparation of metallopeptides with tailored properties for use in biomimetic studies or as building blocks in the design of novel functional materials. This application is particularly relevant for the development of peptide-based catalysts, sensors, or therapeutic research agents where metal coordination imparts desired chemical or structural attributes.
Cellular Signaling Research: The compound is instrumental in dissecting the role of copper-bound peptides in cellular signaling pathways. By introducing controlled amounts of the copper-peptide complex into cell culture or biochemical assays, scientists can monitor downstream effects on gene expression, cell proliferation, or oxidative stress responses. Such investigations help clarify the physiological significance of peptide-metal complexes in cellular homeostasis and the regulation of biological processes mediated by metal ions.
Analytical Method Development: Prezatide Copper Acetate is also employed as a reference standard or calibration compound in analytical techniques aimed at detecting or quantifying peptide-metal complexes. Its well-characterized properties make it suitable for validating methods such as high-performance liquid chromatography (HPLC), mass spectrometry, and spectroscopic assays. By providing a reliable benchmark for method optimization and quality control, it supports the advancement of analytical workflows in peptide research and metallomics.
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