Pro-Ser pairs a turn-inducing proline with polar serine to probe β-turn motifs and local structural rearrangements. The hydroxyl side chain engages in hydrogen bonding that shapes loop geometry. Researchers examine its conformational distribution by NMR and simulation. Applications include motif design, peptide-protein interface modeling, and SPPS optimization studies.
CAT No: R2567
CAS No:71835-80-8
Synonyms/Alias:Pro-Ser;71835-80-8;H-Pro-Ser-OH;L-Serine, N-L-prolyl-;CHEMBL209083;L-prolyl-L-serine;(2S)-3-hydroxy-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoic acid;prolyl-serine;CHEBI:73648;prolylserine;L-Pro-L-Ser;MFCD00083811;SCHEMBL25365110;DTXSID70428595;BDBM50188510;AKOS010408212;DA-54089;FP108163;Q27143819;(2S)-3-hydroxy-2-{[(2S)-pyrrolidin-2-yl]formamido}propanoic acid;P-S;
Pro-Ser, also known as Proline-Serine dipeptide, is a synthetic carbohydrate compound that combines the amino acids proline and serine through a peptide bond. This dipeptide is widely recognized for its stability and solubility in aqueous solutions, making it a versatile tool for research and development across multiple scientific disciplines. Its unique structure facilitates interactions with various biomolecules, which enables it to play a significant role in biochemical and molecular biology studies. Pro-Ser is valued for its ease of incorporation into peptide synthesis workflows, allowing researchers to investigate the structure-function relationships of proteins and peptides. The compound's compatibility with a range of analytical techniques further enhances its utility in laboratory settings, supporting advanced research into protein engineering and metabolic processes.
Peptide Synthesis Research: Proline-Serine dipeptide is extensively used as a building block in solid-phase peptide synthesis, enabling the creation of custom peptides for research purposes. Its presence in peptide chains can influence the overall conformation and stability of the resulting molecule, thus providing valuable insights into protein folding and function. By incorporating this dipeptide into synthetic peptides, scientists can systematically study the effects of specific amino acid sequences on biological activity, which is essential for the design of novel bioactive peptides and the exploration of structure-activity relationships.
Enzyme Substrate Studies: In enzymology, Pro-Ser serves as a model substrate for investigating the specificity and catalytic mechanisms of proteases and peptidases. Researchers utilize this dipeptide to examine how enzymes recognize and cleave peptide bonds, particularly those involving proline and serine residues. The insights gained from such studies contribute to a deeper understanding of enzyme function and substrate selectivity, which can inform the development of enzyme inhibitors or mimetics for research applications.
Protein Engineering: The incorporation of Pro-Ser into recombinant proteins or synthetic constructs allows scientists to probe the effects of dipeptide motifs on protein structure, stability, and function. By strategically inserting this motif, researchers can assess its impact on protein folding pathways and the formation of secondary structural elements, such as turns or loops. This approach is instrumental in designing proteins with enhanced properties or novel functionalities for use in biotechnology and fundamental research.
Biochemical Assays: Proline-Serine dipeptide is frequently employed as a standard or control in a variety of biochemical assays, including those that measure proteolytic activity or peptide transport. Its defined structure and predictable behavior make it an ideal reference compound for calibrating assay conditions and validating experimental results. Utilizing this dipeptide in assay development ensures reproducibility and reliability, which are critical for generating high-quality data in biochemical research.
Metabolic Pathway Analysis: Researchers investigating metabolic pathways often use Pro-Ser to trace the fate of dipeptides in cellular systems. By tracking the uptake, hydrolysis, and utilization of this compound, scientists can elucidate the mechanisms underlying peptide transport and catabolism in different organisms. Such studies provide valuable information about nutrient processing, cellular metabolism, and the regulation of peptide-based signaling networks, thereby advancing our understanding of fundamental biological processes.
Structural Biology Investigations: In structural biology, Pro-Ser is incorporated into peptide models to study conformational preferences and intermolecular interactions. Its distinct backbone geometry and side chain characteristics make it a useful probe for exploring the structural determinants of peptide folding and stability. By analyzing the behavior of this dipeptide in various environments, researchers can gain insights into the principles governing protein architecture and dynamics, which are essential for rational design in protein science and biomaterials development.
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