Protein SSX2 (45-59)

Protein SSX2 (45-59) is a synthetic peptide fragment corresponding to amino acids 45 through 59 of the SSX2 protein, a member of the synovial sarcoma X breakpoint (SSX) family of proteins. Recognized for its involvement in chromatin remodeling and transcriptional regulation, SSX2 is of particular interest in studies of gene expression and epigenetic control. The 45-59 region encompasses a sequence that may play a role in protein-protein interactions, making this peptide fragment a valuable tool for research into the molecular functions and binding partners of SSX2. Its defined sequence and structural features enable precise investigations into the biochemical and cellular roles of SSX2 in both normal and disease-associated pathways.

Epitope mapping: Utilization of the SSX2 (45-59) peptide is instrumental in mapping antibody epitopes within the SSX2 protein. By providing a defined linear sequence, researchers can assess antibody specificity and binding affinity in immunological assays such as ELISA, Western blotting, and immunoprecipitation. This approach aids in the development of highly specific detection reagents for SSX2, facilitating studies on its expression patterns and cellular localization in various biological contexts.

Protein interaction studies: The peptide fragment serves as a critical probe for analyzing interactions between SSX2 and its potential binding partners. In vitro assays employing the 45-59 region allow for the identification and characterization of proteins or small molecules that associate with this segment. Such studies contribute to elucidating the molecular mechanisms underlying SSX2-mediated transcriptional regulation and chromatin dynamics, offering insights into its broader role in cellular processes.

Peptide-functional analysis: As a representative segment of the SSX2 protein, the 45-59 peptide supports functional studies aimed at deciphering the biological significance of this specific region. Researchers can employ the peptide in assays designed to investigate its influence on cellular signaling pathways, post-translational modifications, or structural motifs. This targeted approach enables a detailed dissection of SSX2 function at the molecular level, advancing understanding of its contribution to gene regulation.

Immunogenicity research: The SSX2 (45-59) peptide is frequently used to evaluate T-cell or B-cell responses in immunological studies. By serving as a defined antigenic determinant, it enables the assessment of immune recognition and activation in experimental systems. Such applications are particularly relevant for exploring the immunological properties of SSX2 in the context of autoimmunity or oncogenic transformation, providing a foundation for further investigation into immune surveillance mechanisms.

Peptide synthesis validation: The defined sequence and moderate length of this SSX2-derived fragment make it an ideal reference standard or control in peptide synthesis workflows. Analytical laboratories and peptide manufacturers can employ the peptide to optimize synthesis protocols, monitor purity, and validate analytical methods such as mass spectrometry or HPLC. This ensures the reliability and reproducibility of peptide-based reagents used in a wide range of biochemical and molecular biology applications.

1. Exosomes-mediated Transfer of miR-125a/b in Cell-to-cell Communication: A Novel Mechanism of Genetic Exchange in the Intestinal Microenvironment

2. Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis

3. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

4. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

5. Myotropic activity of allatostatins in tenebrionid beetles