Teriparatide is a recombinant human parathyroid hormone analogue that is used to treat osteoporosis in women or men with a high risk for bone fracture. Teriparatide therapy has not been associated with serum aminotransferase elevations during therapy and has not been implicated in instances of clinically apparent liver injury.
CAT No: P6924
CAS No:52232-67-4
Synonyms/Alias:52232-67-4;Teriparatide acetate hydrate;Parathyroid Hormone (Human, 1-34);PTH-4068-S;PTH-4068-V;EX-A7393;AKOS034831562;Human parathyroid hormone-(1-34);hPTH (1-34);(4S)-4-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-3-car;H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH;Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn- Phe, Teriparatide (synthetic);Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn- Phe, Teriparatide (synthetic);
Chemical Name:(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
Teriparatide, a synthetic peptide fragment corresponding to the biologically active region of human parathyroid hormone (PTH 1-34), is widely recognized for its unique ability to stimulate bone formation through direct action on osteoblasts. As a research-grade compound, Teriparatide offers invaluable opportunities for the study of bone metabolism, calcium homeostasis, and cellular signaling pathways involved in skeletal health. Its molecular structure allows for precise interactions with the parathyroid hormone 1 receptor (PTH1R), making it an essential tool in elucidating the mechanisms underlying bone remodeling and mineralization. Researchers value the compound for its stability, ease of handling in experimental protocols, and reproducible biological activity, which collectively support a broad spectrum of scientific investigations in endocrinology, physiology, and tissue engineering.
Bone Metabolism Research: Teriparatide is extensively utilized in fundamental studies investigating the regulation of bone turnover. By mimicking the endogenous activity of parathyroid hormone, it enables researchers to dissect the anabolic effects on osteoblast differentiation, proliferation, and survival. In in vitro and in vivo models, Teriparatide administration helps clarify the temporal dynamics of bone matrix synthesis and mineral deposition, offering insights into the molecular drivers of bone formation and resorption. These studies are critical for advancing the understanding of skeletal development, age-related bone loss, and the interplay between hormonal signaling and mechanical loading in bone health.
Osteoblast and Osteoclast Signaling Pathways: The peptide fragment serves as a powerful probe in studies aiming to delineate the cellular signaling cascades activated by PTH1R engagement. Researchers leverage Teriparatide to map downstream effectors such as cyclic AMP, protein kinase A, and Wnt signaling pathways, which collectively orchestrate the balance between bone-building osteoblasts and bone-resorbing osteoclasts. This mechanistic insight is instrumental for identifying novel therapeutic targets and for optimizing strategies to modulate bone density and architecture in experimental settings.
Calcium Homeostasis Investigations: The compound is frequently employed in research focused on systemic calcium regulation. Through its capacity to influence renal calcium reabsorption, intestinal absorption, and skeletal mobilization, Teriparatide provides a model system for studying the hormonal control of calcium flux in the body. These studies contribute to a more nuanced understanding of mineral balance, parathyroid gland physiology, and the hormonal adaptations to dietary or metabolic challenges, informing broader research in endocrinology and metabolism.
Tissue Engineering and Regenerative Medicine: In the context of tissue engineering, researchers incorporate Teriparatide into biomaterial scaffolds, cell culture systems, and animal models to promote bone regeneration and repair. Its anabolic properties are harnessed to stimulate osteogenesis, enhance the integration of implants, and accelerate the healing of critical-sized bone defects. The compound's role in modulating the local bone microenvironment makes it a valuable adjunct in the development of next-generation materials and strategies for skeletal reconstruction and functional restoration.
Pharmacological Screening and Drug Discovery: Teriparatide is a reference compound in pharmacological assays designed to identify and characterize new agents targeting bone metabolism. By serving as a positive control or comparator, it enables the evaluation of novel small molecules, peptides, or biologics that aim to replicate or surpass its bone-forming efficacy. These applications are essential for advancing the pipeline of experimental therapeutics and for refining the preclinical assessment of candidate drugs with potential applications in bone health and metabolic research.
In summary, Teriparatide stands as a versatile and scientifically robust tool across diverse research domains, from basic bone biology and signal transduction to regenerative medicine and pharmacological innovation. Its distinctive mechanism of action and compatibility with a wide array of experimental models make it indispensable for scientists seeking to unravel the complexities of bone physiology, mineral homeostasis, and tissue repair. By facilitating high-impact studies, the compound continues to drive progress in understanding skeletal disorders, improving biomaterial design, and expanding the landscape of bone-targeted drug discovery.
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