Teriparatide is a recombinant human parathyroid hormone analogue that is used to treat osteoporosis in women or men with a high risk for bone fracture. Teriparatide therapy has not been associated with serum aminotransferase elevations during therapy and has not been implicated in instances of clinically apparent liver injury.
CAT No: P6924
CAS No:52232-67-4
Synonyms/Alias:52232-67-4;Teriparatide acetate hydrate;Parathyroid Hormone (Human, 1-34);PTH-4068-S;PTH-4068-V;EX-A7393;AKOS034831562;Human parathyroid hormone-(1-34);hPTH (1-34);(4S)-4-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-3-car;H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH;Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn- Phe, Teriparatide (synthetic);Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn- Phe, Teriparatide (synthetic);
Chemical Name:(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
Teriparatide is a recombinant peptide fragment corresponding to the biologically active 1-34 amino acid sequence of human parathyroid hormone (PTH). As a synthetic peptide analog, teriparatide retains the full spectrum of receptor-binding and signaling properties characteristic of endogenous PTH, making it a valuable tool in studies of calcium homeostasis, bone metabolism, and peptide hormone-receptor interactions. Its well-defined structure and functional mimicry of native PTH allow for precise interrogation of downstream signaling pathways, cellular responses, and regulatory mechanisms involved in mineral ion balance. The availability of teriparatide as a research-grade peptide enables detailed experimental exploration of parathyroid hormone biology and its broader physiological implications.
Receptor Binding Studies: Teriparatide serves as a critical reagent for investigating the molecular mechanisms of PTH receptor (PTH1R) activation and downstream signaling. Its defined sequence and high affinity for PTH1R facilitate studies on ligand-receptor interactions, conformational changes, and G-protein coupling events. Researchers utilize the peptide to dissect the structural determinants of receptor specificity, affinity modulation, and the kinetics of receptor-ligand engagement, providing insights into the pharmacodynamics of PTH analogs and their potential as research tools in cellular signaling.
Bone Metabolism Research: The peptide is widely employed in in vitro and ex vivo systems to model the effects of parathyroid hormone on bone-forming osteoblasts and bone-resorbing osteoclasts. By stimulating PTH-responsive pathways, teriparatide enables the study of cellular processes such as proliferation, differentiation, and matrix mineralization. These models are essential for elucidating the molecular basis of bone remodeling, understanding anabolic and catabolic responses, and identifying new regulatory factors involved in skeletal biology.
Calcium Homeostasis Studies: Teriparatide is instrumental in experiments designed to probe the regulation of calcium flux, transport, and storage in various cell types and tissue models. Its ability to activate PTH-dependent signaling cascades allows researchers to examine the modulation of calcium channels, pumps, and transporters. These studies contribute to a deeper understanding of systemic mineral ion regulation, paracrine and autocrine signaling in mineralizing tissues, and the adaptive responses of cells to fluctuating extracellular calcium concentrations.
Peptide Structure-Function Analysis: As a well-characterized synthetic peptide, teriparatide is frequently used in structure-activity relationship (SAR) studies aimed at mapping the functional domains essential for receptor binding and biological activity. By introducing targeted modifications or employing analogs, researchers can assess the impact of specific amino acid residues or structural motifs on peptide conformation, stability, and receptor activation. Such work supports the rational design of novel peptide ligands and enhances the understanding of peptide hormone evolution.
Peptide Synthesis and Analytical Method Development: Teriparatide provides a benchmark for optimizing solid-phase peptide synthesis protocols, purification strategies, and analytical characterization techniques. Its defined sequence and established bioactivity make it an ideal standard for validating chromatographic methods, mass spectrometric analyses, and bioassays used in peptide research. These applications are vital for ensuring the accuracy and reproducibility of peptide-based experimental workflows across academic and industrial laboratories.
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