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Q-VD-OPH

Q-VD-OPH is a broad-spectrum caspase inhibitor that blocks caspases-3, -7, -8, -9, -10, and -12. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Q-VD-OPH(CAS 1135695-98-5)

CAT No: R0812

CAS No:1135695-98-5

Synonyms/Alias:1135695-98-5;Q-VD-OPh;Q-VD-OPh hydrate;QVD-OPH;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic Acid;(3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid;(S)-5-(2,6-Difluorophenoxy)-3-((S)-3-methyl-2-(quinoline-2-carboxamido)butanamido)-4-oxopentanoic acid;N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl ketone;pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-;Quinoline-Val-Asp-Difluorophenoxymethylketone;MFCD08669741;CHEMBL4237988;SCHEMBL15449978;DTXSID90647322;C26H25F2N3O6;CHEBI:232611;EX-A1093;s7311;AKOS027446655;CCG-269797;CS-6252;AC-31505;BS-14641;FD103285;HY-12305;N-(2-Quinolinyl)valyl-aspartyl (2,6-difluorophenoxy)methyl ketone;(3S)-5-(2,6-DIFLUOROPHENOXY)-3-[(2S)-3-METHYL-2-(QUINOLIN-2-YLFORMAMIDO)BUTANAMIDO]-4-OXOPENTANOIC ACID;(3S)-5-(2,6-Difluorophenoxy)-4-oxo-3-{[N-(quinoline-2-carbonyl)-L-valyl]amino}pentanoic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C26H25F2N3O6
M.W/Mr.
513.5
Application
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
Appearance
White to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Activity
Inhibitor
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
InChI
InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1
InChI Key
OOBJCYKITXPCNS-REWPJTCUSA-N
Isomeric SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2

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