RF9 is an NPFF1 and NPFF2 inhibitor
CAT No: R1882
CAS No:876310-60-0
Synonyms/Alias:876310-60-0;RF9;2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE;1-Adamantanecarbonyl-RF-NH2;RF9 trifluoroacetate salt;CHEMBL1672380;1-adamantanecarbonyl-Arg-Phe-NH2;RF 9;RF 9 TFA;GTPL1486;SCHEMBL18041259;CHEBI:140980;DTXSID001151466;BDBM50336912;AKOS024457741;CS-7903;NCGC00485847-01;AS-77961;DA-67180;FR108335;PD045604;PD119376;HY-107382;D93586;Q27088538;N2-(Tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide;N(2)-(tricyclo[3.3.1.1(3,7)]decan-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide;Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide;
Chemical Name:N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide
RF 9 is a synthetic peptide compound recognized for its role as a potent and selective antagonist of neuropeptide FF (NPFF) receptors. Structurally designed to mimic endogenous peptide ligands, RF 9 is widely utilized in neurobiological and pharmacological research to interrogate the physiological and signaling pathways mediated by NPFF and related RFamide peptides. Its specificity and stability make it a valuable molecular tool for dissecting the complex regulatory networks involved in pain modulation, neuroendocrine functions, and behavioral responses. As a research-use peptide, RF 9 provides a critical platform for advancing understanding of peptide signaling systems in both central and peripheral contexts.
Receptor pharmacology: RF 9 is extensively applied in studies aiming to elucidate the pharmacological properties and downstream signaling mechanisms of NPFF receptors, particularly NPFF1 and NPFF2 subtypes. By selectively blocking these receptors, researchers can differentiate between NPFF-mediated effects and those arising from other RFamide-related peptides, enabling precise mapping of receptor-ligand interactions. This approach is instrumental in characterizing receptor specificity, affinity, and the molecular determinants of peptide recognition within the RFamide family.
Neurobiology of pain: The peptide serves as a key tool in experimental models investigating the central and peripheral mechanisms of pain perception and modulation. By antagonizing NPFF receptors, RF 9 allows researchers to probe the endogenous roles of NPFF in nociceptive signaling, opioid tolerance, and hyperalgesia. Its use facilitates the delineation of peptide-mediated pathways that influence the efficacy and adaptation of analgesic responses, providing insights into the neurochemical substrates of pain processing.
Neuroendocrine regulation: RF 9 is employed to study the influence of NPFF signaling on neuroendocrine systems, including the hypothalamic-pituitary axis and related hormonal cascades. By inhibiting NPFF receptor activity, investigators can assess the contributions of RFamide peptides to the regulation of stress responses, reproductive hormone secretion, and energy balance. Such studies advance the understanding of how neuropeptidergic systems integrate environmental and physiological cues to modulate endocrine function.
Behavioral neuroscience: In behavioral research, RF 9 is utilized to dissect the role of NPFF and related peptides in modulating stress, anxiety, feeding, and social behaviors. Its receptor antagonism enables the selective attenuation of NPFF-driven signaling, allowing for the assessment of peptide-specific effects on complex behavioral phenotypes. This application supports the identification of novel neurochemical pathways underlying behavioral adaptation and homeostasis.
Peptide signaling pathway analysis: As a structurally defined peptide antagonist, RF 9 is an effective probe in cellular and molecular studies aimed at unraveling the broader signaling networks governed by RFamide peptides. Its application in in vitro and ex vivo systems enables the detailed examination of second messenger cascades, receptor cross-talk, and regulatory feedback loops modulated by NPFF receptor activity. These investigations contribute to a systems-level understanding of peptide signaling dynamics in both neuronal and non-neuronal tissues.
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