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  5. [Sar9,Met(O2)11]-Substance P

[Sar9,Met(O2)11]-Substance P

[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
[Sar9,Met(O2)11]-Substance P(CAS 110880-55-2)

CAT No: R1133

CAS No:110880-55-2

Synonyms/Alias:Bhsar-SP;110880-55-2;(Sar(9))SP sulfone;9-Sar-substance P sulfone;Sarcosyl(9)-substance P sulfone;9-Sar-11-met(O2)-substance P;(Sar(9),met(O2)(11))SP;[Sar9,Met(O2)11]-SUBSTANCE P;9-Sarcosyl-11-methionine(O2)-substance P;Bolton hunter-9-sar-11-met(02)-substance P;Sar9, Met (O2)11-Substance P;MFCD00076787;CHEMBL1651026;Substance P, sar(9) sulfone;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2;(Sar9,Met(O2)11)-Substance P;Substance P, sar(9)-met(O2)(11)-;Substance P, sarcosyl(9)-methionine(O2)(11)-;Bolton-hunter reagent-substance P. sar(9)-met(02)(11);Substance P, sarcosyl(9)-methionine(02)(11)-bhr;[Sar9, Met(O2)11]-Substance P;8V0QAFPRXV;UNII-8V0QAFPRXV;(Sar(9)kMet(O(2))(11))-substance P;[sar9,met(o2)11]-substance-p;OUPXSLGGCPUZJJ-SARDKLJWSA-N;Substance P [Sar9,Met(O2)11];(Sar 9,Met(O2)11)-Substance P;BDBM50335566;AKOS024456442;DB05875;Substance P, 9-(N-methylglycine)-11-(4-(methylsulfonyl)-L-2-aminobutanamide)-;NCGC00167322-01;FS110428;G12248;[Sar...9...,Met(O..2..)...11...]substance P;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2; H-RPKPQQFF(Sar)L(MetO2)-NH2;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C64H100N18O15S
M.W/Mr.
1393.7
Sequence
One Letter Code:RPKPQQFFGLX
Three Letter Code:H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2
Appearance
White or off-white lyophilized powder
Purity
≥97% (HPLC)
Activity
Potent selective NK1 tachykinin receptor agonist.
Long-term Storage Conditions
Soluble to 1 mg/ml in water
InChI
InChI=1S/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
InChI Key
OUPXSLGGCPUZJJ-SARDKLJWSA-N
Canonical SMILES
[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O

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