[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.
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CAT No: R1133
CAS No:110880-55-2
Synonyms/Alias:Bhsar-SP;110880-55-2;(Sar(9))SP sulfone;9-Sar-substance P sulfone;Sarcosyl(9)-substance P sulfone;9-Sar-11-met(O2)-substance P;(Sar(9),met(O2)(11))SP;[Sar9,Met(O2)11]-SUBSTANCE P;9-Sarcosyl-11-methionine(O2)-substance P;Bolton hunter-9-sar-11-met(02)-substance P;Sar9, Met (O2)11-Substance P;MFCD00076787;CHEMBL1651026;Substance P, sar(9) sulfone;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2;(Sar9,Met(O2)11)-Substance P;Substance P, sar(9)-met(O2)(11)-;Substance P, sarcosyl(9)-methionine(O2)(11)-;Bolton-hunter reagent-substance P. sar(9)-met(02)(11);Substance P, sarcosyl(9)-methionine(02)(11)-bhr;[Sar9, Met(O2)11]-Substance P;8V0QAFPRXV;UNII-8V0QAFPRXV;(Sar(9)kMet(O(2))(11))-substance P;[sar9,met(o2)11]-substance-p;OUPXSLGGCPUZJJ-SARDKLJWSA-N;Substance P [Sar9,Met(O2)11];(Sar 9,Met(O2)11)-Substance P;BDBM50335566;AKOS024456442;DB05875;Substance P, 9-(N-methylglycine)-11-(4-(methylsulfonyl)-L-2-aminobutanamide)-;NCGC00167322-01;FS110428;G12248;[Sar...9...,Met(O..2..)...11...]substance P;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2; H-RPKPQQFF(Sar)L(MetO2)-NH2;
[Sar9,Met(O2)11]-Substance P is a synthetic peptide analogue of the neuropeptide Substance P, characterized by the substitution of sarcosine at position 9 and the oxidation of methionine to methionine sulfone at position 11. These modifications confer increased metabolic stability, making it a valuable tool for probing the structure-activity relationships and receptor interactions of tachykinins in neurobiological and pharmacological research. The peptide is widely recognized for its role in studies investigating neurotransmission, neuropeptide signaling, and cellular responses mediated by neurokinin receptors, particularly the NK1 subtype. Its resistance to enzymatic degradation and altered binding properties make it a preferred choice for delineating the functional roles of Substance P and its analogues in both in vitro and ex vivo systems.
Receptor pharmacology: In the context of receptor pharmacology, [Sar9,Met(O2)11]-Substance P is frequently employed to characterize the binding affinities, selectivity, and activation profiles of neurokinin (NK) receptors, especially NK1. Its enhanced stability allows for more precise assessment of ligand-receptor interactions, enabling researchers to dissect the molecular determinants of receptor activation, desensitization, and downstream signaling. These studies are essential for advancing the understanding of tachykinin-mediated pathways and for the development of novel receptor modulators.
Neuropeptide signaling research: The peptide serves as a robust model compound in studies investigating the mechanisms of neuropeptide signaling. By mimicking the structure of endogenous Substance P while offering improved resistance to peptidase degradation, it facilitates the exploration of synaptic transmission, neuronal excitability, and neuropeptide-induced cellular responses. Researchers utilize it to elucidate the physiological and pathophysiological roles of Substance P in neural tissues and peripheral organs, providing insights into the modulation of pain, inflammation, and neurogenic processes.
Peptide structure-activity relationship (SAR) studies: [Sar9,Met(O2)11]-Substance P is a critical tool in SAR investigations aimed at mapping the functional domains of tachykinin peptides. The specific amino acid modifications incorporated into its sequence allow scientists to assess the impact of structural changes on receptor binding, signal transduction, and biological activity. These studies inform the rational design of new analogues with tailored pharmacological profiles, contributing to the broader understanding of peptide-receptor interactions.
Peptide stability and degradation analysis: Due to its resistance to enzymatic breakdown, this analogue is utilized as a reference compound in studies examining peptide stability, degradation kinetics, and metabolic fate in biological matrices. Such research is vital for optimizing peptide-based probes, evaluating the influence of structural modifications on peptide half-life, and improving the design of experimental protocols that require sustained bioactivity in complex environments.
Analytical method development: The distinctive chemical modifications present in [Sar9,Met(O2)11]-Substance P make it an excellent standard for validating and calibrating analytical techniques, including high-performance liquid chromatography (HPLC) and mass spectrometry, used for peptide detection and quantification. Its defined structure and predictable chromatographic behavior support the development and optimization of sensitive assays for tachykinin peptides in research samples, enhancing the reliability and reproducibility of neuropeptide analysis.
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