Satoreotide Tetraxetan features a somatostatin-analog peptide linked to a tetraxetan chelator suitable for radiometal coordination studies. Cyclic backbone constraints promote defined receptor-binding conformations. Researchers investigate its metal-loading behavior, stability, and stereochemical preferences. Use spans receptor-ligand modeling, coordination chemistry, and radiometal-chelate optimization in preclinical systems.
CAT No: R2539
CAS No:1039726-31-2
Synonyms/Alias:DOTA satoreotide;Satoreotide DOTA;Satoreotide tetraxetan;EC1O2FB9FV;DOTA-JR-11;1039726-31-2;UNII-EC1O2FB9FV;DOTA-JR11;satoreotida tetraxetan;SATOREOTIDE TETRAXETAN [INN];D-TYROSINAMIDE, 4-CHLORO-N-(2-(4,7,10-TRIS(CARBOXYMETHYL)-1,4,7,10-TETRAAZACYCLODODEC-1-YL)ACETYL)-L-PHENYLALANYL-D-CYSTEINYL-4-((((4S)-HEXAHYDRO-2,6-DIOXO-4-PYRIMIDINYL)CARBONYL)AMINO)-L-PHENYLALANYL-4-((AMINOCARBONYL)AMINO)-D-PHENYLALANYL-L-LYSYL-L-THREONYL-L-CYSTEINYL-, CYCLIC (2->7)-DISULFIDE;satoreotidum tetraxetanum;CHEMBL4297531;EX-A5520;HY-P5128;DA-63000;CS-0775089;
Satoreotide Tetraxetan is a sophisticated carbohydrate-based compound designed for research applications in peptide chemistry and molecular imaging. Structurally, it integrates a somatostatin receptor-targeting peptide with a chelating agent, enabling the formation of stable complexes with various metal ions. This unique combination facilitates site-specific delivery and detection in biological systems, making Satoreotide Tetraxetan a valuable tool in advanced biochemical investigations. Its molecular architecture supports selective binding to somatostatin receptors, which are overexpressed in certain pathological tissues, thereby offering targeted approaches for a range of experimental protocols. The compound's versatility lies in its dual functionality, providing both targeting and chelation capabilities that are highly sought after in modern research settings.
Receptor Targeting Studies: Satoreotide Tetraxetan serves as a pivotal agent in studies focusing on somatostatin receptor expression and distribution. Researchers utilize it to probe receptor density and localization in various cell lines and tissue samples, leveraging its high affinity and specificity. By conjugating the compound with appropriate metal ions, investigators can employ imaging or detection techniques to map receptor presence, supporting fundamental research into receptor-mediated signaling pathways and potential therapeutic targets.
Radiolabeling and Molecular Imaging: In the realm of molecular imaging, Satoreotide Tetraxetan is frequently employed as a chelator for radiometal labeling. Its robust chelating moiety allows for the secure attachment of diagnostic radioisotopes, which can then be visualized using imaging modalities such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT). This application enables the non-invasive visualization of biological processes in vivo, facilitating the assessment of receptor expression, tissue distribution, and pharmacokinetics in preclinical models.
Peptide Conjugation Research: The compound's design supports efficient conjugation with a variety of peptides and biomolecules, making it a valuable component in the development of targeted molecular probes. Scientists exploit its bifunctional nature to create conjugates that retain high receptor affinity while incorporating imaging or detection functionalities. This capability is particularly useful for constructing multifunctional agents that can simultaneously target, detect, and quantify biomolecular interactions, advancing the study of complex biological systems.
Metal Ion Chelation Investigations: Satoreotide Tetraxetan's chelating properties are harnessed in research focused on metal ion coordination chemistry. By forming stable complexes with a range of metal ions, the compound aids in elucidating the behavior of chelated biomolecules under physiological conditions. These studies contribute to a deeper understanding of metal ion transport, stability, and reactivity in biological environments, which is crucial for the design of novel diagnostic and research agents.
Pharmacokinetic and Biodistribution Studies: Researchers utilize Satoreotide Tetraxetan in experimental protocols aimed at elucidating the pharmacokinetics and biodistribution of labeled peptides and conjugates. By tracking the in vivo behavior of the compound, investigators gain insights into tissue uptake, retention, and clearance mechanisms. These data are essential for optimizing the design of targeted agents and for predicting their performance in subsequent studies, thereby enhancing the overall efficiency of research workflows.
Satoreotide Tetraxetan's multifaceted characteristics make it indispensable in the fields of receptor targeting, radiolabeling, peptide conjugation, metal ion chelation, and pharmacokinetic research. Its ability to combine specific receptor affinity with robust chelation chemistry underpins a wide array of investigative strategies, supporting the advancement of scientific knowledge in molecular imaging, biochemical analysis, and targeted probe development. As research continues to evolve, Satoreotide Tetraxetan remains a cornerstone for innovative experimental approaches that require precision, reliability, and versatility in carbohydrate-based compound applications.
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