Seglitide Acetate is a peptide analog containing helix-supporting residues and acidic-basic pairs that tune receptor interaction. The acetate form enhances solubility and handling. Researchers evaluate its conformational behavior in solution and binding to structured targets. Applications include SAR exploration, receptor-motif mapping, and synthetic analog development.
CAT No: R2400
CAS No:99248-33-6
Synonyms/Alias:Seglitide acetate;99248-33-6;Seglitide acetate [USAN];UNII-URM20C99DG;URM20C99DG;MK-678;Seglitide (acetate);Seglitide acetate (USAN);DTXSID80244001;acetic acid;(3S,6S,9S,12R,15S,18S)-9-(4-aminobutyl)-3-benzyl-15-[(4-hydroxyphenyl)methyl]-12-(1H-indol-3-ylmethyl)-1,18-dimethyl-6-propan-2-yl-1,4,7,10,13,16-hexazacyclooctadecane-2,5,8,11,14,17-hexone;CYCLIC(N-ME-ALA-TYR-D-TRP-LYS-VAL-PHE) ACETATE;Cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl) monoacetate (salt);CYCLO(N-METHYL-L-ALANYL-L-TYROSYL-D-TRYPTOPHYL-L-LYSYL-L-VALYL-L-PHENYLALANYL), ACETATE (1:1);Cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl)-monoacetate (salt).;SCHEMBL242685;CHEMBL2103887;DTXCID40166492;GDA37702;AKOS040749474;HY-106103A;TS-08626;CS-0088855;D05812;Q27291225;
Seglitide Acetate is a synthetic peptide analog designed to interact selectively with specific biological receptors involved in metabolic regulation. Characterized by its stability and high affinity for its molecular targets, this compound has become a valuable tool in biochemical and pharmacological research. Its structural features allow for precise modulation of receptor-mediated pathways, making it especially useful in dissecting complex signaling networks. Researchers appreciate Seglitide Acetate for its predictable behavior in experimental systems and its compatibility with a variety of in vitro and in vivo models. The compound's versatility and specificity have led to its adoption in multiple investigative domains, where it supports the elucidation of mechanisms underlying metabolic and endocrine processes.
Metabolic Pathway Investigation: In metabolic research, Seglitide Acetate serves as a powerful probe for exploring the regulation of energy balance and nutrient utilization. By modulating the activity of target receptors, it enables scientists to dissect the contributions of specific signaling cascades to glucose and lipid metabolism. Its application in these studies helps clarify how peptide hormones influence metabolic homeostasis and provides insights into the molecular basis of metabolic disorders. Using Seglitide Acetate, researchers can manipulate key nodes within these pathways, facilitating the identification of novel regulatory mechanisms and potential intervention points.
Endocrine Function Analysis: The study of peptide-receptor interactions in the endocrine system benefits greatly from the use of Seglitide Acetate. Its ability to selectively engage with its receptor makes it ideal for examining hormone secretion dynamics and feedback regulation. In experimental setups, it is often employed to assess the downstream effects of receptor activation or inhibition, thereby illuminating the physiological roles of specific endocrine axes. This approach aids in unraveling the complex interplay between different hormonal systems and supports the development of refined models of endocrine control.
Receptor Binding Assays: As a reference ligand in receptor binding assays, Seglitide Acetate provides a reliable means to quantify receptor-ligand interactions. Its defined affinity and specificity allow for the calibration of assay systems and the benchmarking of new compounds. Researchers utilize it to determine binding constants, assess receptor occupancy, and study competitive binding dynamics. These applications are critical for advancing our understanding of receptor pharmacology and for the screening of novel modulators with therapeutic potential.
Signal Transduction Research: Seglitide Acetate is instrumental in delineating the downstream signaling events triggered by receptor activation. By serving as a selective agonist or antagonist in cell-based assays, it enables the mapping of intracellular pathways and the identification of key signaling intermediates. This information is essential for constructing detailed models of signal transduction and for pinpointing molecular targets that may be amenable to pharmacological intervention. The compound's use in these studies accelerates the discovery of new signaling paradigms and enhances the precision of pathway analysis.
Structure-Activity Relationship Studies: In medicinal chemistry and peptide engineering, Seglitide Acetate is frequently used as a template for structure-activity relationship (SAR) investigations. By systematically modifying its sequence or chemical structure, scientists can assess the impact of specific changes on receptor affinity and biological activity. These SAR studies inform the rational design of next-generation analogs with improved properties, supporting the advancement of peptide-based research tools and potential therapeutic candidates. The insights gained from such work contribute to the broader understanding of peptide-receptor interactions and the optimization of ligand design for diverse applications.
2. Implications of ligand-receptor binding kinetics on GLP-1R signalling
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
5. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More