Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome. 1-2 Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2 All of these peptides are released into cytosol from mitochondria. SHLP3 shares protective effects with Humanin, such as eduction in apoptosis, generation of reactive oxygen species and improving mitochondrial metabolism. In addition, it may participate in age-related disease pathology. 1-2
CAT No: X21190
1. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
3. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
5. TMEM16F and dynamins control expansive plasma membrane reservoirs
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