SOR-C13 emerges as a paradigm-shifting therapeutic solution against multifarious cancer phenotypes. Employing an ingenious mechanism, this potent compound efficaciously obstructs the nefarious SORCIN protein, thereby orchestrating a comprehensive blockade on the pernicious proliferation and dissemination of malignant tumors. Exuding its benevolence, SOR-C13 illumines a path of sanguine expectations for those afflicted with lung, breast, prostate, and ovarian cancer, heralding a captivating era of tailor-made therapeutic interventions in the intricate realm of oncology.
CAT No: R2062
CAS No:1187852-48-7
Synonyms/Alias:SOR-C13;UNII-C79B5A73C4;1187852-48-7;C79B5A73C4;L-Arginine, L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-leucyl-L-histidyl-L-prolyl-L-seryl-L-lysyl-L-valyl-L-alpha-aspartyl-L-leucyl-L-prolyl-;(4S)-5-(((1S)-2-(((1S)-1-(((1S)-2-((2S)-2-(((1S)-2-(((1S)-5-Amino-1-(((1S)-1-(((1S)-1-(((1S)-1-((2S)-2-(((1S)-1-carboxy-4-guanidino-butyl)carbamoyl)pyrrolidine-1-carbonyl)-3-methyl-butyl)carbamoyl)-3-hydroxy-3-oxo-propyl)carbamoyl)-2-methyl-propyl)ca;L-ARGININE, L-LYSYL-L-.ALPHA.-GLUTAMYL-L-PHENYLALANYL-L-LEUCYL-L-HISTIDYL-L-PROLYL-L-SERYL-L-LYSYL-L-VALYL-L-.ALPHA.-ASPARTYL-L-LEUCYL-L-PROLYL-;CHEMBL4228250;GTPL12562;BDBM50459973;DB15366;DA-58010;TRPV6 Calcium Channel Inhibitor SOR-C13;Q27895873;H-Lys-Glu-Phe-Leu-His-Pro-Ser-Lys-Val-Asp-Leu-Pro-Arg-OH;
Chemical Name:(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoic acid
SOR-C13 is a synthetic peptide compound designed to selectively target and modulate specific calcium channels involved in cellular signaling pathways. As a member of the peptide family, SOR-C13 is characterized by its unique amino acid sequence, which confers high affinity for transient receptor potential (TRP) channels, particularly TRPV6. This selectivity makes it a valuable tool for researchers investigating calcium influx mechanisms, cellular homeostasis, and signal transduction. Its biochemical profile and molecular specificity have positioned it as an important reagent for the study of peptide-channel interactions, intracellular calcium regulation, and the downstream effects of altered calcium dynamics in various biological systems.
Ion Channel Research: SOR-C13 is widely used in studies focused on the functional characterization of TRPV6 calcium channels. By acting as a selective modulator, the peptide enables researchers to dissect the physiological and biochemical roles of this channel in calcium uptake and signaling. Application of SOR-C13 in electrophysiological assays, calcium imaging, and patch-clamp experiments facilitates the identification of channel-specific currents, gating properties, and pharmacological sensitivities. This targeted approach helps elucidate the contribution of TRPV6 to cellular calcium homeostasis, offering insight into fundamental ion channel biology.
Cellular Signaling Pathway Analysis: In the context of signal transduction, SOR-C13 serves as a molecular probe to investigate how TRPV6-mediated calcium entry influences downstream signaling cascades. Researchers employ the peptide to modulate intracellular calcium concentrations, thereby enabling the study of calcium-dependent kinases, phosphatases, and transcription factors. Its application in cell-based assays supports the dissection of pathways involved in cell proliferation, apoptosis, and differentiation, enhancing understanding of how calcium dynamics orchestrate complex cellular responses.
Peptide-Protein Interaction Studies: The unique sequence and structural features of SOR-C13 make it an effective tool for mapping peptide-protein interactions, particularly those involving calcium channel complexes. By introducing the peptide into in vitro binding assays, surface plasmon resonance experiments, or co-immunoprecipitation protocols, scientists can assess affinity, specificity, and interaction kinetics with target proteins. These studies provide valuable data for the development of novel modulators and for understanding the molecular determinants of peptide-channel recognition.
Calcium Homeostasis and Transport Investigations: SOR-C13 is instrumental in probing the mechanisms underlying calcium transport and homeostatic regulation within various cell types. Its selective inhibition of TRPV6 allows researchers to quantify the impact of channel activity on intracellular and extracellular calcium levels using fluorescence-based assays, radiotracer uptake measurements, or atomic absorption spectroscopy. Such applications are critical for delineating the physiological roles of calcium channels in epithelial tissues, glandular secretion, and mineral absorption processes.
Peptide Pharmacology and Structure-Activity Relationship (SAR) Studies: As a synthetic peptide with defined channel specificity, SOR-C13 is frequently utilized in pharmacological profiling and SAR analyses. Researchers synthesize analogs or truncated variants to determine the structural motifs responsible for channel binding and functional modulation. These studies inform the rational design of next-generation peptide modulators, contributing to a deeper understanding of the relationship between peptide sequence, structure, and biological activity. The knowledge gained from such investigations supports the broader field of peptide-based research and aids in the development of selective tools for interrogating ion channel function.
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