Spadin

Effective TREK-1 channel blocker (IC50 = 71 nM) that enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects.

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CAT#R1093
CAS1270083-24-3
Synonyms/AliasL-tyrosyl-L-alanyl-L-prolyl-L-leucyl-L-prolyl-L-arginyl-L-tryptophyl-L-serylglycyl-L-prolyl-L-isoleucylglycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine;
M.F/FormulaC96H142N26O22
M.W/Mr.2012.34
SequenceOne Letter Code: YAPLPRWSGPIGVSWGLR
Three Letter Code: Tyr-Ala-Pro-Leu-Pro-Arg-Trp-Ser-Gly-Pro-Ile-Gly-Val-Ser-Trp-Gly-Leu-Arg
ActivityInhibitor
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