Spantide I is a peptide analog enriched in aromatic and charged residues that shape its conformational landscape. The sequence supports investigations of ligand-binding motifs, helix-loop transitions, and solvent-driven dynamics. Researchers employ it to explore structural determinants of peptide recognition. Its defined architecture aids high-resolution mechanistic studies.
CAT No: R2323
CAS No:91224-37-2
Synonyms/Alias:Spantide I;91224-37-2;MFCD00076805;D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE;[D-Arg1, D-Trp7,9, Leu11]-Substance P;Spantide I TFA;CHEMBL439284;SAPCBHPQLCZCDV-CHPWDEGWSA-N;AKOS024456776;NCGC00167314-01;DA-67711;FA108555;L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-;(D-Arg1,D-Trp7.9,Leu11)-Substance P;(D-Arg1,D-Trp7?9,Leu11)-Substance P;H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; H-(dR)PKPQQ(dW)F(dW)LL-NH2;
Spantide I is a synthetic peptide antagonist derived from the neuropeptide substance P, notable for its ability to selectively block neurokinin-1 (NK1) receptors. As a member of the tachykinin peptide family, Spantide I holds significant value in neuropharmacological and immunological research, providing a robust tool for the investigation of substance P-mediated signaling pathways. Its structure allows researchers to dissect the complex roles of neuropeptides in cellular communication, inflammation, and nociception, making it a widely recognized reagent in studies focused on peptide-receptor interactions and downstream biological effects.
Neuropharmacology research: Spantide I is extensively employed to elucidate the physiological and pathological roles of substance P and NK1 receptors in the central and peripheral nervous systems. By competitively inhibiting substance P binding, it enables researchers to delineate the contribution of NK1 receptor activation to neurotransmission, pain processing, and neurogenic inflammation. Its use is instrumental in both in vitro and in vivo experimental models to parse the molecular mechanisms underlying neuropeptide signaling.
Inflammation and immune modulation studies: The peptide antagonist is a valuable asset in exploring the interplay between neuropeptides and immune responses. By blocking NK1 receptors, Spantide I allows for the assessment of substance P's role in modulating cytokine release, leukocyte trafficking, and vascular permeability during inflammatory processes. This facilitates a deeper understanding of neuro-immune crosstalk and aids in identifying potential molecular targets involved in inflammatory pathophysiology.
Peptide receptor characterization: Researchers utilize Spantide I in receptor binding assays and functional studies to characterize the specificity, affinity, and downstream signaling properties of neurokinin receptors. Its well-defined antagonistic action provides a high degree of selectivity, enabling precise mapping of receptor subtypes and their functional consequences in various cell types and tissue preparations. These studies are crucial for advancing knowledge of receptor pharmacodynamics and for supporting the development of novel neuropeptide-based probes.
Peptide structure-activity relationship (SAR) investigations: The synthetic nature and defined sequence of Spantide I make it a useful model for SAR analyses within the tachykinin family. By comparing its activity to that of native peptides and other analogs, researchers can identify structural determinants critical for receptor binding and antagonism. Such insights are valuable for rational peptide design, optimization of ligand-receptor interactions, and the creation of next-generation peptide-based research tools.
Analytical and detection assay development: Spantide I serves as a reference standard and competitive ligand in a range of analytical methodologies, including high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays. Its application in assay development supports the quantification of neuropeptides and their analogs, validation of detection platforms, and assessment of peptide stability or degradation under experimental conditions. These capabilities are essential for ensuring accuracy and reproducibility in neuropeptide research workflows.
2. Implications of ligand-receptor binding kinetics on GLP-1R signalling
4. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
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