Spantide I is a peptide analog enriched in aromatic and charged residues that shape its conformational landscape. The sequence supports investigations of ligand-binding motifs, helix-loop transitions, and solvent-driven dynamics. Researchers employ it to explore structural determinants of peptide recognition. Its defined architecture aids high-resolution mechanistic studies.
CAT No: R2323
CAS No:91224-37-2
Synonyms/Alias:Spantide I;91224-37-2;MFCD00076805;D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE;[D-Arg1, D-Trp7,9, Leu11]-Substance P;Spantide I TFA;CHEMBL439284;SAPCBHPQLCZCDV-CHPWDEGWSA-N;AKOS024456776;NCGC00167314-01;DA-67711;FA108555;L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-;(D-Arg1,D-Trp7.9,Leu11)-Substance P;(D-Arg1,D-Trp7?9,Leu11)-Substance P;H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; H-(dR)PKPQQ(dW)F(dW)LL-NH2;
Spantide I, also known as D-Arg¹, D-Trp⁷,⁹, Leu¹¹-substance P, is a synthetic peptide antagonist designed to inhibit the biological activity of substance P, a neuropeptide involved in various physiological and pathological processes. Characterized by its high specificity and affinity for neurokinin-1 (NK-1) receptors, Spantide I has become a valuable tool in neuropharmacological research. Its unique structure allows it to effectively block substance P-mediated signaling, making it instrumental in studies investigating the roles of neuropeptides in inflammation, pain transmission, and immune responses. The stability and solubility of Spantide I further enhance its utility in both in vitro and in vivo experimental settings, supporting a broad range of scientific investigations into neurogenic mechanisms.
Neuropharmacology research: Spantide I is extensively utilized in neuropharmacology to elucidate the role of substance P in neurotransmission and synaptic modulation. By acting as a competitive antagonist at NK-1 receptors, it enables researchers to dissect the contribution of substance P to various neural circuits and behavioral outcomes. Its application in electrophysiological studies and receptor binding assays has provided critical insights into the modulation of pain pathways, mood regulation, and the development of neurogenic inflammation. Through these investigations, Spantide I has helped clarify the mechanisms underlying neuropeptide signaling and receptor interactions within the central and peripheral nervous systems.
Inflammation studies: In the context of inflammation, Spantide I serves as a potent inhibitor of substance P-induced pro-inflammatory responses. Researchers employ it to block the activation of NK-1 receptors on immune and endothelial cells, thereby attenuating the release of cytokines, chemokines, and other inflammatory mediators. This approach has proven valuable in models of acute and chronic inflammation, where the peptide's antagonistic properties allow for the delineation of substance P's role in promoting vascular permeability, leukocyte recruitment, and tissue edema. By mitigating these responses, Spantide I provides a mechanistic framework for understanding neurogenic inflammation and the interplay between the nervous and immune systems.
Pain mechanism exploration: The study of pain pathways has greatly benefited from the use of Spantide I as a research tool. It is frequently applied in experimental models of nociception to inhibit substance P-mediated transmission of pain signals. By blocking NK-1 receptor activation on sensory neurons, Spantide I helps to clarify the contribution of neuropeptides to hyperalgesia, allodynia, and the development of chronic pain states. Its use in these models supports the identification of novel targets for pain modulation and enhances the understanding of neurochemical changes associated with injury or disease.
Allergy and respiratory research: Spantide I has found significant applications in allergy and respiratory studies, where substance P is known to contribute to bronchoconstriction, airway hyperresponsiveness, and mucosal inflammation. By antagonizing NK-1 receptors, the peptide is used to investigate the neurogenic components of asthma and allergic rhinitis in preclinical models. This research sheds light on the interactions between sensory nerves and immune cells in the airways, offering new perspectives on the regulation of respiratory inflammation and hypersensitivity reactions.
Dermatological investigations: In dermatological research, Spantide I is instrumental in exploring the neuroimmune mechanisms underlying skin inflammation and hypersensitivity. Substance P plays a crucial role in mediating cutaneous responses such as vasodilation, pruritus, and mast cell degranulation. By inhibiting these pathways, Spantide I allows scientists to study the impact of neuropeptide signaling on skin barrier function, immune cell recruitment, and the pathogenesis of inflammatory skin disorders. Its application in these studies contributes to a deeper understanding of the complex interactions between the nervous system and skin health, fostering the development of innovative strategies for managing neurogenic skin conditions.
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