Teriparatide Impurity 3 (Teri-Met18(O)) features oxidation of methionine at position 18 to methionine sulfoxide. The modification increases polarity and perturbs local side-chain packing. Researchers monitor its formation to evaluate oxidative stability and degradation pathways. Applications include stress-testing studies, impurity specification, and redox-chemistry characterization in peptide formulations.
CAT No: Z10-101-228
Synonyms/Alias:Teriparatide Impurity 3 (Teri-Met 18(O)); L-seryl-L-valyl-L-seryl-L-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl(O)-L-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine; Met(O)18-Teriparatide; H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met(O)-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
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