Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).
CAT No: R1715
CAS No:141685-53-2
Synonyms/Alias:141685-53-2;H-SER-PHE-LEU-LEU-ARG-OH;Thrombin Receptor Activator for Peptide 5 (TRAP-5);L-Arginine, L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-;TRAP-5 trifluoroacetate salt;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid;Ser42-Phe-Leu-Leu-Arg46;(2S,5S,8S,11S,14S)-14-Amino-11-benzyl-2-(3-guanidinoPropyl)-15-hydroxy-5,8-diisobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid;SFLLR-OH;P5;Ser-Phe-Leu-Leu-Arg;Thrombin Receptor Activator for Peptide 5 TRAP-5;BDBM85088;DTXSID80649491;HY-P1536;AKOS030525615;DA-78585;FT108440;PD099870;H-Ser-Phe-Leu-Leu-Arg-OH; H-SFLLR-OH;CS-0044800;L-Seryl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithine;(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-phenylpropanamido]-4-methylpentanamido]-4-methylpentanamido]-5-carbamimidamidopentanoic acid;
Thrombin Receptor Activator for Peptide 5 TRAP-5 is a synthetic peptide designed to selectively activate protease-activated receptor-1 (PAR-1), a key transmembrane receptor involved in thrombin-mediated cellular signaling. As a potent and specific PAR-1 agonist, TRAP-5 has become an essential tool in the study of platelet physiology, vascular biology, and intracellular signaling pathways associated with thrombotic and inflammatory processes. Its defined sequence and controlled activity profile allow researchers to dissect the complex roles of thrombin and PAR-1 independent of the proteolytic activity of native thrombin, thereby facilitating precise experimental modulation of receptor activation in a wide range of biochemical and cellular systems.
Platelet Function Assays: TRAP-5 is widely utilized in platelet aggregation studies to mimic thrombin-induced activation through PAR-1 without the confounding effects of fibrin formation or other protease activities. By providing a reproducible and controllable means of stimulating platelets, it enables detailed analysis of platelet reactivity, aggregation kinetics, and downstream signaling events. This application is particularly valuable in the characterization of platelet function in both normal and pathological states, as well as in the assessment of anti-platelet agents targeting PAR-1-mediated pathways.
Vascular Biology Research: In vascular endothelial and smooth muscle cell studies, TRAP-5 serves as a critical reagent for probing the cellular responses to PAR-1 activation. It supports investigations into endothelial barrier function, vascular permeability, and the regulation of inflammatory mediators. By isolating the effects of PAR-1 engagement from other thrombin actions, researchers can elucidate the specific contributions of this receptor to vascular homeostasis, inflammation, and remodeling processes.
Signal Transduction Analysis: The peptide is instrumental in dissecting intracellular signaling cascades initiated by PAR-1 activation. TRAP-5 facilitates the exploration of G-protein-coupled receptor signaling, including the activation of phospholipase C, calcium mobilization, MAP kinase pathways, and other downstream effectors. This targeted approach aids in the mapping of receptor-specific signaling networks and enhances understanding of how PAR-1 modulates cellular function in various physiological and pathophysiological contexts.
Drug Discovery and Screening: TRAP-5 is frequently employed in high-throughput screening assays and preclinical studies aimed at identifying and characterizing novel modulators of PAR-1 activity. Its defined mechanism of action allows for the evaluation of small molecules, antibodies, or peptides intended to inhibit or potentiate PAR-1-mediated signaling. By providing a reliable and specific agonist, it streamlines the development and validation of new therapeutic candidates targeting thrombin receptor pathways.
Peptide Structure-Activity Relationship Studies: As a synthetic PAR-1 agonist, TRAP-5 is also valuable for structure-activity relationship (SAR) investigations within the peptide research field. Modifications to its sequence or structure can be systematically evaluated for their impact on receptor activation potency, selectivity, and downstream signaling profiles. Such studies contribute to the rational design of improved PAR-1 modulators and expand the repertoire of peptide-based tools available for mechanistic research in thrombosis, inflammation, and vascular biology.
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