This peptide is derived from thrombospondin and represents a binding motif responsible for thrombospondin-CD36 interaction. It is cyclized through a disulfide bond. Thrombospondin is a matrix-bound glycoprotein involved in cancer metastasis, tumor adhesion, and angiogenesis. This peptide has been shown to competitively inhibit platelet aggregation and tumor metastasis.
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M.W/Mr. | 566.7 |
Sequence | One Letter Code: CSVTCG (S-S Bonded) Three Letter Code: H-Cys-Ser-Val-Thr-Cys-Gly-OH(S-S Bonded) |
References | 1. Wakiyama, T. et al. Histol Histopathol 16, 345 (2001); 2. Tsuzynski, G. et al. J Cell Biol 120, 513 (1993); 3. Asch, A. et al. Biochem Biophys Res Commun 182, 1208 (1992). |
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