Thymocartin is a regulatory peptide composed of polar, aromatic, and charged residues that modulate flexibility and secondary-structure formation. Researchers examine its conformational adaptability, protein-interface behavior, and side-chain cooperation. The motif supports biophysical mapping and mechanistic evaluation. Its sequence allows high-resolution analytical characterization.
CAT No: R2234
CAS No:85466-18-8
Synonyms/Alias:Thymocartin;85466-18-8;Thymocartine;Thymocartin [INN];Thymocartina;Thymocartinum;Arg-Lys-Asp-Val;Thymocartine [INN-French];Thymocartinum [INN-Latin];Thymocartina [INN-Spanish];Rgh 0206;timocartina;H-arg-lys-asp-val-oh;UNII-M0H0SK3AD5;RGH-0206;M0H0SK3AD5;DTXSID20234688;N-(N-(N(sup 2)-L-Arginyl-L-lysyl)-L-alpha-aspartyl)-L-valine;(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid;L-Valine, N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-;L-Valine, N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-;THYMOPOIETIN II (32-35);Thymocartine (INN-French);Thymocartinum (INN-Latin);Thymocartina (INN-Spanish);(6S,9S,12S,15S)-1,6-diamino-9-(4-aminobutyl)-12-(carboxymethyl)-1-imino-15-isopropyl-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid;N-(N-(N2-L-ARGINYL-L-LYSYL)-L-.ALPHA.-ASPARTYL)-L-VALINE;TP4 peptide;TP-4 tetrapeptide;thymopoietin (32-35);arginyl-lysyl-aspartyl-valine;RGH 0206; TP 4;SCHEMBL443972;CHEMBL2104516;DTXCID50157179;AKOS040754200;HY-105025;CS-0024724;NS00120768;Q27283305;N-(N-(N2-L-ARGINYL-L-LYSYL)-L-ALPHA-ASPARTYL)-L-VALINE;
Thymocartin, also known as thymosin beta-4 fragment or TB4 (1-4), is a synthetic tetrapeptide derived from the N-terminal sequence of thymosin beta-4, a naturally occurring peptide found in various tissues. With its compact structure and high water solubility, Thymocartin offers unique biochemical properties that make it a valuable tool in a range of scientific research applications. Its ability to mimic critical regions of the parent protein enables researchers to investigate specific cellular processes without the complexity associated with longer peptide chains. The stability of Thymocartin in aqueous environments and its compatibility with various assay systems further enhance its utility in experimental settings, supporting studies that require precise modulation of peptide-mediated pathways.
Cell Migration Studies: Thymocartin is widely employed in cell biology research to elucidate the mechanisms underlying cell migration. By acting as a functional analog of the active site of thymosin beta-4, it can be used to stimulate or inhibit the movement of cells in vitro, allowing scientists to dissect the signaling pathways involved in tissue regeneration, wound healing, and cellular response to injury. Its defined sequence facilitates reproducible results in scratch assays, transwell migration experiments, and real-time cell tracking, providing critical insights into actin cytoskeleton dynamics and the regulation of cell motility.
Angiogenesis Research: In the context of vascular biology, TB4 (1-4) serves as a key molecule for probing the molecular events that drive angiogenesis. Researchers utilize it to investigate how short peptide fragments influence endothelial cell behavior, including proliferation, migration, and tube formation. By incorporating Thymocartin into in vitro angiogenesis models, it becomes possible to parse the contributions of specific peptide motifs to the orchestration of new blood vessel formation, which is essential for understanding tissue development and pathological neovascularization.
Extracellular Matrix Remodeling: The application of Thymocartin extends to studies focused on extracellular matrix (ECM) dynamics. Its interaction with ECM components allows for the exploration of matrix metalloproteinase (MMP) regulation and the modulation of cell-matrix adhesion. Scientists leverage this peptide to assess how modifications in ECM structure affect cellular signaling and tissue architecture, particularly in the context of fibrosis, tissue engineering, and organoid culture systems. Its small size and defined activity profile facilitate controlled experimentation in both two-dimensional and three-dimensional matrix environments.
Signal Transduction Analysis: Thymosin beta-4 fragment plays a pivotal role in dissecting intracellular signaling cascades related to peptide-receptor interactions. Through its targeted action, it provides a simplified model for studying the downstream effects of thymosin family peptides on G-actin sequestration, integrin activation, and the modulation of Rho family GTPases. Utilizing Thymocartin in biochemical assays and reporter gene systems enables the identification of novel signaling nodes and the characterization of peptide-mediated cross-talk between cytoskeletal and transcriptional regulators.
Peptide Drug Discovery: Researchers in pharmaceutical sciences employ Thymocartin as a reference compound or structural template in the development of novel peptide-based therapeutics. Its well-defined sequence and activity make it suitable for structure-activity relationship (SAR) studies, high-throughput screening, and the rational design of peptide mimetics. By comparing the biological effects of Thymocartin with those of other peptide fragments, scientists can optimize lead compounds for enhanced stability, receptor selectivity, and functional efficacy, accelerating the discovery of next-generation biomolecules for diverse biomedical applications.
Wound Healing Models: In experimental wound healing models, the use of TB4 (1-4) provides a robust platform for evaluating the peptide's contribution to tissue repair processes. Its application in cell culture and ex vivo tissue systems allows for the quantitative assessment of re-epithelialization, matrix deposition, and cell proliferation. By integrating Thymocartin into these models, researchers can delineate the specific steps influenced by small peptide fragments, enabling a deeper understanding of regenerative biology and the development of innovative strategies for tissue restoration. Through its multifaceted applications across cell biology, vascular research, matrix biology, signal transduction, and drug discovery, Thymocartin continues to serve as a powerful tool for advancing fundamental and translational science.
2. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More