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Trp(4-hydroxybenzyl)25-Semaglutide

Trp(4-hydroxybenzyl)25-Semaglutide contains a modified tryptophan residue offering additional π-stacking and hydrogen-bonding potential. Researchers investigate how the 4-hydroxybenzyl moiety alters folding, receptor binding, and hydrophobic packing. The analog provides insights into semaglutide's structure-activity determinants. Applications include peptide engineering, analog comparison, and conformational analysis.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R2863

Synonyms/Alias:H-His-Aib-Glu-Gly-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gln-Gln-Ala-Ala-Lys-(Oct-gamma-AEEAc-AEEAA)Glu-Phe-lle-Ala-Trp(p-OH-Benzyl)-Leu-Val-Arg-Gly-Arg-Gly-OH; (3S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81S)-3-(2-((R)-2-Amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-54-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-21-((2-(4-hydroxybenzyl)-1H-indol-3-yl)methyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic Acid;

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  • Drug master files (DMF) filing
M.F/Formula
C194H297N45O60
M.W/Mr.
4219.77
Sequence
Three Letter Code:H-His-Aib-Glu-Gly-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys (AEEAc-AEEAc-γ-Glu-17-carboxy heptadecanoyl)-Glu-Phe-Ile-Ala-Trp(p-OH-Benzyl)-Leu-Val-Arg-Gly-Arg-Gly-OH

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