Vipivotide Tetraxetan consists of a peptide vector linked to a tetraxetan chelator optimized for radiometal coordination in receptor-targeted research. The peptide motif directs binding, while the macrocyclic chelator ensures controlled metal complexation. Researchers assess stability, binding geometry, and solution behavior. Applications include radiometal-ligand modeling, receptor-mapping studies, and chelator-optimization projects.
CAT No: PI-026
CAS No:1702967-37-0
Synonyms/Alias:Vipivotide tetraxetan;PSMA-617;1702967-37-0;PSMA617 TFA;DKFZ-PSMA-617;PSMA617;4YM1W0EGQ5;Vipivotide tetraxetan [INN];Vipivotide tetraxetan [USAN];Vipivotide tetraxetan (PSMA-617);1702967-37-0 (free base);(((S)-1-Carboxy-5-((S)-3-(naphthalen-2-yl)-2-((1r,4S)-4-((2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl)cyclohexane-1-carboxamido)propanamido)pentyl)carbamoyl)-L-glutamic acid;(2S)-2-[[(1S)-1-carboxy-5-[[(2S)-3-naphthalen-2-yl-2-[[4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]methyl]cyclohexanecarbonyl]amino]propanoyl]amino]pentyl]carbamoylamino]pentanedioic acid;(((S)-1-carboxy-5-((S)-3-(naphthalen-2-yl)-2-((1r,4S)-4-((2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl)cyclohexane-1-carboxamido)propanamido)pentyl)carbamoyl)-L-glutamic acid tetra(trifluoroacetic acid);L-Lysine, N2-((((1S)-1,3-dicarboxypropyl)amino)carbonyl)-N6-(3-(2-naphthalenyl)-N-(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetyl)-L-alanyl-trans-4-(aminomethyl)cyclohexanecarbonyl)-;N-((N6-(3-(Naphthalen-2-yl)-N-(trans-4-((2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl)cyclohexane-1-carbonyl)-L-alanyl)-llysin-N2-yl)carbonyl)-L-glutamic acid;N2-((((1S)-1,3-Dicarboxypropyl)amino)carbonyl)-N6-(3-(2-naphthalenyl)-N-((trans-4-(((2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetyl)amino)methyl)cyclohexyl)carbonyl)-L-alanyl)-L-lysine;Vipivotida tetraxetan;UNII-4YM1W0EGQ5;CHEMBL4594280;SCHEMBL20180896;SCHEMBL21316439;SCHEMBL21501570;GTPL11982;PSMA-617?;Vipivotide tetraxetan (USAN/INN);Vipivotide tetraxetan [USAN:INN];CTC96737;EX-A5885;BDBM50544833;s8670;WHO 11010;AKOS040735693;DA-77204;MS-31892;HY-117410;CS-0065894;D11697;F82270;-LYSINE, N2-((((1S)-1,3-DICARBOXYPROPYL)AMINO)CARBONYL)-N6-(3-(2-NAPHTHALENYL)-N-((TRANS-4-(((2-(4,7,10-TRIS(CARBOXYMETHYL)-1,4,7,10-TETRAAZACYCLODODEC-1-YL)ACETYL)AMINO)METHYL)CYCLOHEXYL)CARBONYL)--ALANYL)-;PSMA-617; L-Lysine, N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]-; N2-[[[(1S)-1,3-Dicarboxypropyl]amino]carbony;
Vipivotide tetraxetan is a synthetic peptide chelator designed for high-affinity binding of radiometals, particularly in the context of targeted molecular imaging and radiopharmaceutical research. Structurally, it consists of a peptide backbone conjugated to a macrocyclic chelating moiety, enabling site-specific radiolabeling with a variety of medically and scientifically relevant isotopes. Its modular design allows for precise conjugation to targeting vectors, such as antibodies or peptides, facilitating the development of advanced probes for preclinical and translational research. The unique combination of peptide chemistry and chelator functionality makes vipivotide tetraxetan a valuable tool in the expanding field of molecular imaging and radionuclide-based applications.
Radiolabeling research: Vipivotide tetraxetan serves as a robust chelating agent for the incorporation of radiometals, such as lutetium-177 or yttrium-90, into biomolecular constructs. Its macrocyclic core provides exceptional thermodynamic stability and kinetic inertness, ensuring that the radiometal remains securely bound during in vitro and in vivo studies. Researchers leverage this stability to create radiolabeled conjugates for biodistribution, pharmacokinetics, and receptor-targeting investigations, enabling precise tracking of molecular interactions and biological pathways.
Peptide conjugation studies: The peptide-based structure of this compound allows for site-selective attachment to various biological ligands, including monoclonal antibodies, receptor ligands, and small peptides. Through established conjugation chemistries, scientists can generate highly defined bioconjugates that retain both the targeting specificity of the ligand and the radiometal-binding capacity of the chelator. This capability is instrumental in the customization of molecular probes for cell surface receptor mapping, internalization assays, and preclinical imaging model development.
Molecular imaging probe development: In the field of preclinical imaging, vipivotide tetraxetan is utilized for the synthesis of radiometal-labeled probes tailored to specific biological targets. By enabling the stable attachment of diagnostic isotopes to targeting moieties, it supports the creation of agents for single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging. This application is critical for noninvasive visualization of biological processes, receptor expression, and disease models in animal studies, facilitating the evaluation of new biomarkers and investigational agents.
Radiopharmaceutical research tool: As a multifunctional chelator, this compound underpins the development of novel radiopharmaceutical constructs for research use. Its compatibility with a range of radiometals and targeting ligands allows for the systematic exploration of structure-activity relationships, radiochemistry optimization, and pharmacological profiling. Such studies provide essential data for the rational design of next-generation radiolabeled agents, supporting innovation in molecular targeting strategies and probe optimization.
Analytical method development: Vipivotide tetraxetan and its radiolabeled derivatives are also employed in the refinement of analytical techniques, including high-performance liquid chromatography (HPLC), mass spectrometry, and radio-TLC. These applications enable researchers to assess labeling efficiency, conjugate integrity, and radiochemical purity, which are essential parameters for quality control in radiolabeling workflows. The compound's well-characterized properties make it an ideal reference material for validating analytical methods and ensuring reproducibility in radiopharmaceutical research.
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