Z-Asp(OSu)-OBzl is a protected aspartic acid derivative featuring an Asp side chain modified as an N-succinimidyl ester (OSu) and a benzyl ester at the C-terminal carboxyl group (OBzl), with the α-amino function masked by a benzyloxycarbonyl (Z) protecting group. The molecule contains an activated carboxylate equivalent at the side chain for amide-bond formation, while the Z and benzyl ester groups control chemoselectivity by reducing undesired reactions of the α-amino and C-terminal carboxyl functionalities during peptide-coupling or conjugation steps. Z-Asp(OSu)-OBzl is used as a building block and coupling reagent in peptide synthesis and chemical biology workflows where an aspartate-derived electrophilic handle is required for attaching the molecule to nucleophiles such as amines under controlled conditions.
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