Z-Lys(Tos)-ONp is a protected lysine derivative in which the α-amino group is carbobenzyloxy (Z/Cbz) protected and the ε-amino side chain is tosylated (Tos), while the carboxyl terminus is present as a p-nitrophenyl ester (ONp). The molecule bears an ε-(tosylamino) functionality that reduces nucleophilicity of the side-chain amine and an activated p-nitrophenyl ester that can undergo acyl transfer under appropriate conditions, with stereochemistry not specified in the name. Z-Lys(Tos)-ONp is used as a building block and acylating intermediate for peptide-related synthesis and for preparing lysine-containing amide or peptide derivatives, where orthogonal protection and carboxyl activation support controlled stepwise coupling and downstream deprotection strategies.
1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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