Z-Sar-OSu

Name: Z-Sar-OSu
Brand: Creative Peptides
Rating: 5 (1 reviews)

Z-Sar-OSu is a protected amino acid derivative in which Sar (sarcosine, N-methylglycine) is converted to an activated N-hydroxysuccinimide ester (OSu) and the amino functionality is acylated with a benzyloxycarbonyl (Z, Cbz) protecting group. The molecule bears a Z-protected amide/urethane-type nitrogen and a carboxyl group masked as the succinimide ester, providing an electrophilic carbonyl that can undergo acyl transfer while the Z group controls chemoselectivity by reducing undesired reactions at the amino site. Z-Sar-OSu is used in peptide coupling and related synthesis as an activated carboxylate equivalent, enabling formation of amide bonds with nucleophiles under conditions where succinimide ester activation is appropriate, and it can also serve as a defined intermediate for preparing further amino acid and peptide derivatives.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP25882

CAS No:53733-96-3

Synonyms/Alias:Z-Sar-OSu;53733-96-3;2,5-dioxopyrrolidin-1-yl2-{[(benzyloxy)carbonyl](methyl)amino}acetate;AmbotzZAA1261;SCHEMBL7285217;CTK8G3899;MolPort-008-269-467;ZINC2526272;7675AB;AKOS016003032;AK-81340;AM025243;HE020547;KB-281500;FT-0698547;K-9715;3B3-062471;2,5-Dioxo-1-pyrrolidinylN-[(benzyloxy)carbonyl]-N-methylglycinate

Chemical Name:N-alpha-Benzyloxycarbonyl-sarcosine succinimidyl ester, N-alpha-Benzyloxycarbonyl-N-alpha-Methyl-glycine succinimidyl ester

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C15H16N2O6

M.W/Mr.

320,3 g/mole

Size

5 g;25 g;

InChI

1S/C15H16N2O6/c1-16(15(21)22-10-11-5-3-2-4-6-11)9-14(20)23-17-12(18)7-8-13(17)19/h2-6H,7-10H2,1H3

InChI Key

GUHSSKCYLZIGBH-UHFFFAOYSA-N

Canonical SMILES

CN(CC(=O)ON1C(=O)CCC1=O)C(=O)OCC2=CC=CC=C2

1. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

2. Odorant binding protein based biomimetic sensors for detection of alcohols associated with Salmonella contamination in packaged beef

3. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

4. Cationic cell-penetrating peptides are potent furin inhibitors

5. Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line

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