Ac-Tyr-Val-Ala-Asp-AFC

Ac-Tyr-Val-Ala-Asp-AFC is a fluorogenic substrate designed for measuring protease-mediated cleavage events. Its AFC group enables sensitive detection of enzymatic activity through emission-based assays. Researchers employ it to quantify catalytic efficiency and substrate preference. The peptide supports high-throughput profiling of proteolytic mechanisms.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Ac-Tyr-Val-Ala-Asp-AFC(CAS 219137-85-6)

CAT No: C11034

CAS No:219137-85-6

Synonyms/Alias:Ac-YVAD-AFC;219137-85-6;Ac-Tyr-Val-Ala-Asp-AFC;N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin;(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]butanoic acid;MFCD01318881;SCHEMBL5888824;CHEBI:136755;GWKJISJKNKIJNP-DEQDFGQZSA-N;HY-P2377;Ac-L-Tyr-L-Val-L-Ala-L-Asp-AFC;AS-86312;DA-50215;CS-0133617;Ac-Tyr-Val-Ala-Asp-7-Amino-4-trifluoromethylcoumarin;N-Acetyl-Tyr-Val-Ala-Asp-7-amino-4-(trifluoromethyl)coumarin;Caspase-1 substrate (fluorogenic), Caspase-4 substrate (fluorogenic);N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin, >=95% (HPLC), powder;N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C33H36F3N5O10
M.W/Mr.
719.7
Sequence
One Letter Code:YVAD
InChI
InChI=1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1
InChI Key
GWKJISJKNKIJNP-DEQDFGQZSA-N

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