Acetyl decapeptide-3

Acetyl decapeptide-3 is a synthetic peptide composed of ten amino acids, designed for use in advanced cosmetic formulations. Recognized for its biomimetic structure, this ingredient is relevant in products targeting the appearance of aging skin, such as fine lines and loss of elasticity. Its compatibility with a range of formulation types supports its inclusion in serums, creams, and other topical applications aimed at enhancing skin condition and appearance.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CPC1687

Synonyms/Alias:124335-65-5;2-(4-(2-Hydroxyethyl)piperazin-1-yl)acetic acid;[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-acetic acid;[4-(2-Hydroxyethyl)-piperazin-1-yl]-acetic acid;2-[4-(2-hydroxyethyl)piperazin-1-yl]acetic acid;[4-(2-Hydroxyethyl)-1-piperazinyl]acetic Acid;MFCD03444540;[4-(2-hydroxyethyl)piperazin-1-yl]acetic acid;[4-(2-Hydroxyethyl)piperazin-1-yl]aceticacid;1-Piperazineacetic acid, 4-(2-hydroxyethyl)-;BAS 03840560;4-(2-Hydroxyethyl)-1-piperazineacetic acid;SCHEMBL1270440;DTXSID80374736;AC3338;AKOS000300085;FS-5277;SY007369;DB-017409;CS-0312904;2-(4-(2-Hydroxyethyl)piperazin-1-yl)aceticacid;

Chemical Name:(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-amino-N-[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]hexanamide

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C8H16N2O3
M.W/Mr.
188.22
Sequence
One Letter Code: YRSRKYTSWY Three Letter Code: Ac-Tyr-Arg-Ser-Arg-Lys-Tyr-Thr-Ser-Trp-Tyr-NH2
Functions
Reduces and prevents lines and wrinkles by actively generating new skin cells.

Mechanism of Action (MOA)

Acetyl decapeptide-3 is a synthetic biomimetic peptide structurally related to basic fibroblast growth factor (bFGF) sequences. Upon topical application, it is suggested to interact with cell surface receptors involved in cellular signaling pathways, such as those regulating extracellular matrix components. This peptide may support communication between skin cells, encouraging processes associated with epidermal renewal and maintenance, without altering normal physiological functions. Suitable for incorporation into cosmetic formulations targeting skin vitality.

Acetyl decapeptide-3 is suitable for incorporation into a variety of topical cosmetic formulations.

- Facial serums targeting daily skin care routines
- Lightweight emulsions for leave-on treatments
- Sheet masks and hydrogel patches
- Eye contour creams and gels
- Night creams and restorative lotions
- Scalp and hair care products for cosmetic enhancement

INCIName
ACETYL DECAPEPTIDE-3
InChI
InChI=1S/C8H16N2O3/c11-6-5-9-1-3-10(4-2-9)7-8(12)13/h11H,1-7H2,(H,12,13)
InChI Key
VCEKKKPFXABURR-UHFFFAOYSA-N
Canonical SMILES
CC(C(C(=O)NC(CO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C)O
Isomeric SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)C)O

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