Alirinetide exhibits potent anti-inflammatory properties, effectively targeting specific receptors involved in allergic responses. This innovative drug has demonstrated promising results in alleviating symptoms and improving the overall quality of life for patients suffering from conditions such as asthma and allergic rhinitis.
CAT No: R2014
CAS No:725715-18-4
Synonyms/Alias:Alirinetide;725715-18-4;6BK9OEG8CC;GM-608;GM-602;GM-604;GM-606;GM-6;L-Arginine, L-phenylalanyl-L-seryl-L-arginyl-L-tyrosyl-L-alanyl-;UNII-6BK9OEG8CC;ALIRINETIDE [INN];ALIRINETIDE [WHO-DD];L-phenylalanyl-L-seryl-L-arginyl-L-tyrosyl-L-alanyl-L-arginine;GM-603;GM-605;GM-607;GM-609;(2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-Amino-3-phenyl-propanoyl)amino)-3-hydroxy-propanoyl)amino)-5-guanidino-pentanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)-5-guanidino-pentanoic acid;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid;alirinetida;alirinetidum;GM602;GM603;GM605;GM607;GM608;GM609;GM 604;AKOS040751941;DA-70695;HY-107130;CS-0027391;
Chemical Name:(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Alirinetide is a synthetic peptide compound designed to interact with specific molecular targets involved in neurodegenerative processes and cellular stress responses. As a member of the peptide family, it is characterized by a well-defined amino acid sequence that confers unique biochemical properties and functional relevance in experimental systems. Its structure enables precise modulation of protein-protein interactions and signaling pathways, making it highly valuable in the investigation of mechanisms underlying cellular homeostasis, neuroprotection, and related biological phenomena. Researchers utilize Alirinetide to probe peptide-mediated effects in vitro and in vivo, supporting the advancement of peptide-based research and the development of innovative molecular tools.
Neurodegeneration Research: Alirinetide serves as a critical tool in the study of neurodegenerative disorders, where peptide aggregation, misfolding, and cellular toxicity are central to disease progression. Its ability to mimic or modulate endogenous peptide sequences allows scientists to dissect the molecular events leading to neuronal damage and loss. By incorporating this compound into cellular and animal models, researchers can evaluate the impact of specific peptide interactions on neuroinflammation, oxidative stress, and synaptic integrity, ultimately providing insights into the molecular etiology of neurodegenerative conditions.
Protein-Protein Interaction Studies: The defined sequence and structural stability of Alirinetide make it an excellent probe for analyzing protein-protein interactions within complex biological systems. In particular, it can be used to map binding interfaces, assess affinity constants, and characterize the dynamics of peptide-mediated signaling cascades. Such studies enable a deeper understanding of the regulatory networks that govern cellular responses to stress and injury, and facilitate the identification of novel molecular targets for further investigation.
Cellular Stress Response Investigation: Alirinetide is widely utilized to explore cellular mechanisms that protect against or exacerbate stress-induced damage. Its application in models of oxidative or metabolic stress helps elucidate the roles of specific peptides in modulating cell survival pathways, autophagy, and apoptosis. By modulating these processes, the compound assists researchers in unraveling the complex interplay between peptide signaling and cellular adaptation, thereby advancing knowledge in cell biology and stress physiology.
Peptide Synthesis and Analytical Method Development: The synthetic nature of Alirinetide makes it a valuable reference standard in peptide synthesis optimization and analytical assay development. Laboratories employ it to validate chromatographic methods, calibrate mass spectrometry systems, and benchmark peptide purification protocols. Its use as a model compound ensures the reliability and reproducibility of analytical workflows, supporting high-quality peptide research and manufacturing practices.
Functional Assays in Drug Discovery: Alirinetide is frequently incorporated into functional assays aimed at screening for modulators of peptide-driven pathways. By serving as a substrate, inhibitor, or molecular probe in high-throughput screening platforms, it enables the identification and characterization of compounds that influence neuroprotective or cytoprotective mechanisms. Such applications are integral to the early stages of drug discovery, where understanding the functional consequences of peptide interaction is essential for target validation and lead optimization.
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