Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.
CAT No: R1180
CAS No:123338-13-6
Synonyms/Alias:Allatostatin IV;Allatostatiniv;123338-13-6;123374-35-6;(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid;Asp-Arg-Leu-Tyr-Ser-Phe-Gly-Leu-NH2;L-Leucinamide, L-alpha-aspartyl-L-arginyl-L-leucyl-L-tyrosyl-L-seryl-L-phenylalanylglycyl-;DTXSID00474429;(3S)-3-amino-3-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}-2-hydroxyethyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-3-methylbutyl]carbamoyl}but;HY-P1760;Allatostatin IV, >=97% (HPLC);AKOS030633002;Asp-Arg-Leu-Tyr-Ser-Phe-Gly-Leu-amide;AS-74138;DA-70712;PD159271;CS-0095525;D94455;(3S)-3-AMINO-3-{[(1S)-4-CARBAMIMIDAMIDO-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-CARBAMOYL-3-METHYLBUTYL]CARBAMOYL}METHYL)CARBAMOYL]-2-PHENYLETHYL]CARBAMOYL}-2-HYDROXYETHYL]CARBAMOYL}-2-(4-HYDROXYPHENYL)ETHYL]CARBAMOYL}-3-METHYLBUTYL]CARBAMOYL}BUTYL]CARBAMOYL}PROPANOIC ACID;(3S,6S,9S,12S,15S,18S,24S)-3-amino-18-benzyl-24-carbamoyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-15-(hydroxymethyl)-9-isobutyl-26-methyl-4,7,10,13,16,19,22-heptaoxo-5,8,11,14,17,20,23-heptaazaheptacosan-1-oic acid;
Allatostatin IV is a neuropeptide belonging to the allatostatin family, originally characterized in insects for its regulatory effects on juvenile hormone biosynthesis. Structurally, it comprises a specific amino acid sequence that confers high affinity for allatostatin receptors, making it a valuable tool for dissecting neuropeptide signaling pathways. Its unique ability to modulate neuronal activity and influence physiological processes has established it as a critical reagent for researchers investigating neuroendocrine regulation, peptide-receptor interactions, and the evolution of signaling molecules. The compound's distinct biochemical properties support a range of experimental applications, particularly within neurobiology, endocrinology, and comparative physiology.
Neurophysiological research: Allatostatin IV is widely utilized in neurophysiological investigations to elucidate the mechanisms of neural circuit modulation. By applying the peptide to isolated nervous tissues or in vivo models, researchers can observe its inhibitory effects on neuronal firing rates and synaptic transmission. These studies provide insight into the functional roles of allatostatin-like peptides in central and peripheral nervous systems, advancing understanding of inhibitory neurotransmission and neuropeptide-mediated signaling.
Receptor pharmacology: The peptide serves as a precise ligand in receptor binding and activation studies, enabling the characterization of allatostatin receptor subtypes and their downstream signaling pathways. Utilizing radiolabeled or fluorescently tagged forms, scientists can quantify binding affinities, assess receptor specificity, and map expression patterns. Such research is instrumental in deciphering the molecular basis of peptide-receptor interactions and in the development of synthetic analogs for experimental modulation of receptor activity.
Endocrine regulation studies: Allatostatin IV plays a pivotal role in studies focused on hormonal control mechanisms, particularly in insect and arthropod models. Its ability to suppress juvenile hormone synthesis provides a powerful experimental tool for probing the regulation of development, reproduction, and metabolic processes. By manipulating peptide levels or receptor activation, researchers can dissect the interplay between neuropeptide signaling and endocrine outputs, informing broader questions in developmental biology and physiology.
Comparative evolutionary biology: The conserved nature of allatostatin peptides across diverse species makes Allatostatin IV a valuable probe for evolutionary studies. Comparative analyses using the peptide help elucidate the divergence and conservation of neuropeptide signaling systems, shedding light on the molecular evolution of hormonal regulation. Experimental applications include cross-species receptor activation assays and phylogenetic mapping of peptide sequences and functions.
Peptide structure-function analysis: As a well-defined neuropeptide, Allatostatin IV is frequently employed in structure-activity relationship studies to determine the critical residues required for receptor recognition and biological activity. By synthesizing and testing analogs with targeted modifications, researchers can delineate the structural determinants of potency and selectivity. These investigations not only advance fundamental peptide chemistry but also inform the rational design of novel modulators for neuropeptide research.
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