2-amino-3-hydroxy-4-methyl-valeric acid is a substituted amino acid featuring a five-carbon (valeric acid) backbone bearing an amino group and a secondary alcohol at the 3-position with a methyl substituent at the 4-position. The molecule contains the free amino functionality and a carboxylic acid group, and its side-chain hydroxyl provides a polar hydrogen-bonding site that can participate in derivatization or metal coordination while the additional methyl group modulates steric and hydrophobic character. As a chemically defined amino acid building block, it is used in peptide and amino acid derivative synthesis and in structure-property studies where the combination of an amino acid scaffold with a hydroxyl-bearing side chain supports analytical method development and the preparation of more complex, functionalized amino acid analogues.
CAT No: CP07001
2-amino-3-hydroxy-4-methyl-valeric acid is an amino alcohol-containing amino acid building block featuring a secondary hydroxyl group and a branched alkyl side chain. This structure makes it useful as a stereochemically informative intermediate for assembling functionalized amino acid derivatives and for introducing hydroxyl-bearing carbon frameworks into peptide-like and small-molecule scaffolds. In research and development settings, it is typically handled as a free amino acid or closely related intermediate suitable for downstream functional-group transformations and analytical characterization workflows.
1. Functionalized Building Blocks
2-amino-3-hydroxy-4-methyl-valeric acid is used as a hydroxyl-bearing amino acid building block in the synthesis of substituted amino acid derivatives and peptidomimetic fragments where an amino alcohol motif is required. Medicinal chemistry and chemical biology groups commonly incorporate this type of scaffold to modulate hydrogen-bonding patterns and to provide a handle for further derivatization (for example, conversion of the hydroxyl into protected forms or into reactive derivatives for subsequent coupling steps). Pharmaceutical intermediate developers also value the compound as a compact, branched chiral precursor for generating libraries of functionalized analogs used in structure-activity relationship studies.
2. Chiral Intermediate Development
2-amino-3-hydroxy-4-methyl-valeric acid serves as a practical chiral intermediate for route development in specialty chemical manufacturing, particularly when the secondary alcohol and amino functionality must be carried through multi-step sequences. Process chemists and custom synthesis teams use it to access stereodefined carbon frameworks that can later be transformed into protected amino acid derivatives, cyclic or acyclic amino alcohol motifs, and other constrained intermediates. Because the molecule contains two key functional groups in one scaffold, it is frequently selected when downstream chemistry benefits from retaining both nitrogen and oxygen functionality for staged protection/deprotection and conversion strategies.
3. Derivatization For Analytical Chemistry
2-amino-3-hydroxy-4-methyl-valeric acid is employed in analytical method development and reference-material preparation where amino alcohol-containing structures are needed for calibration, identification, or derivatization-based workflows. Laboratories developing LC-MS or GC-MS assays for amino acid derivatives often use such compounds to evaluate derivatization efficiency, chromatographic behavior, and mass spectral response for hydroxylated amino frameworks. Stable and well-defined functional groups also make it useful for preparing standards and internal reference compounds used to monitor sample processing steps that involve amino/oxygen functional-group transformations.
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