Angstrom6 is a urokinase inhibitor potentially for the treatment of chronic lymphocytic leukemia.
CAT No: R1929
CAS No:220334-14-5
Synonyms/Alias:A-6 peptide; A-6; A6; A 6
Chemical Name:(S)-4-((S)-1-(acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl)pyrrolidine-2-carboxamido)-5-(((S)-4-amino-1-carboxy-4-oxobutyl)amino)-5-oxopentanoic acid
Angstrom6 is a synthetic peptide compound designed for advanced biochemical research, notable for its precise amino acid sequence and functional versatility in laboratory settings. As a member of the peptide class, Angstrom6 is engineered to facilitate a range of studies centered on protein interactions, signal transduction, and molecular recognition. Its defined structure and stability make it an attractive tool for researchers seeking to dissect complex biological pathways or develop novel analytical methods. The compound's robust profile supports its integration into experimental workflows focused on peptide-mediated processes, offering valuable insights into fundamental and applied biosciences.
Peptide signaling studies: Angstrom6 is frequently employed in investigations of cellular communication, where it serves as a model substrate or ligand for probing receptor-ligand interactions. By mimicking endogenous peptide motifs, it enables researchers to elucidate the specificity and affinity of peptide-binding proteins, contributing to a deeper understanding of signal transduction mechanisms. Such studies are critical for mapping the molecular underpinnings of cell signaling networks and for identifying potential modulators of these pathways.
Protein-protein interaction assays: The defined sequence of Angstrom6 allows it to act as a selective probe in assays designed to characterize protein-protein interactions. Its application in pull-down assays, surface plasmon resonance, or fluorescence-based detection systems helps clarify binding affinities and interaction domains within complex biological samples. These insights are essential for unraveling the molecular architecture of multi-protein assemblies and for guiding the rational design of interaction inhibitors or mimetics.
Peptide synthesis validation: Angstrom6 also serves as a benchmark compound in the optimization and validation of solid-phase peptide synthesis protocols. Its reproducible properties make it a useful standard for assessing coupling efficiency, purity, and sequence fidelity in synthetic workflows. By providing a reliable reference, it assists peptide chemists in troubleshooting synthesis challenges and ensuring the quality of custom peptide libraries.
Analytical method development: In analytical chemistry, Angstrom6 is valuable for calibrating and validating techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and capillary electrophoresis. Its use as an analytical standard facilitates the development of robust quantitation methods for peptides in complex matrices. This capability is vital for laboratories engaged in biomarker discovery, pharmaceutical analysis, or quality control of peptide-based products.
Structural biology research: The predictable conformation and stability of Angstrom6 make it an excellent candidate for structural studies using techniques like nuclear magnetic resonance (NMR) spectroscopy or X-ray crystallography. By serving as a model system, it aids in elucidating peptide folding patterns, backbone dynamics, and intermolecular interactions. Such research advances the broader understanding of peptide structure-function relationships and informs the rational design of bioactive peptide analogs.
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