BCMA72-80 is a HLA-A2-specific B-cell maturation antigen (BCMA) peptide, with great affinity to HLA-A2, used in the research of multiple myeloma or other B-cell maturation antigen expressing tumors.
BCMA72-80 is a synthetic peptide corresponding to amino acids 72 through 80 of the human B-cell maturation antigen (BCMA), a member of the tumor necrosis factor receptor superfamily. As a peptide fragment derived from a key immunoregulatory protein, BCMA72-80 serves as a valuable molecular tool for research into immune cell signaling, antigen processing, and receptor-ligand interactions. Its defined sequence and functional relevance make it particularly useful in studies exploring the role of BCMA in B-cell biology, immune modulation, and the molecular mechanisms underlying plasma cell differentiation.
Epitope mapping: Researchers utilize BCMA72-80 in epitope mapping experiments to delineate the precise antigenic regions recognized by monoclonal antibodies or T-cell receptors. By incorporating this peptide into binding assays or competitive inhibition studies, investigators can identify critical contact points within the BCMA protein, informing the development of highly specific immunoreagents and improving the understanding of immune recognition mechanisms.
T-cell activation assays: In immunological research, BCMA72-80 is applied in vitro to stimulate antigen-specific T-cell responses. Its defined sequence enables the evaluation of T-cell receptor specificity, cytokine production, and cytotoxic activity in peripheral blood mononuclear cells or engineered T-cell populations. These assays are instrumental in dissecting the role of BCMA-derived epitopes in adaptive immunity and in assessing the immunogenic potential of candidate vaccine components.
Peptide-MHC binding studies: The peptide's sequence is frequently employed in major histocompatibility complex (MHC) binding assays to assess its affinity for various MHC class I or II molecules. Such studies are critical for understanding antigen presentation pathways, predicting immune response profiles, and guiding the rational design of peptide-based immunotherapies or diagnostic reagents.
Autoimmunity and tolerance research: BCMA72-80 is used as a model antigen in studies investigating mechanisms of self-tolerance and autoimmunity. By exposing immune cell cultures or animal models to this peptide, researchers can probe the processes that regulate autoreactive T-cell activation, peripheral tolerance, and the breakdown of immune homeostasis in the context of B-cell-related autoimmune disorders.
Peptide-based assay development: Analytical laboratories incorporate BCMA72-80 into various assay platforms, including enzyme-linked immunosorbent assays (ELISA), flow cytometry, and mass spectrometry, to quantify BCMA-specific immune responses or to validate antibody specificity. Its well-characterized structure and immunological relevance make it a reliable standard or positive control in the development and optimization of peptide-centric analytical methods.
Through these diverse applications, BCMA72-80 provides essential support for advanced immunological research, assay development, and the elucidation of fundamental processes in B-cell biology and immune regulation. Its use enables precise characterization of antigenic determinants, facilitates the study of immune cell function, and advances the development of innovative research tools for the scientific community.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
2. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More