Beinaglutide functions as a mesmerizing glucagon-like peptide-1 receptor agonist, impeccably orchestrating the delicate dance of blood sugar regulation. By deftly summoning the release of insulin while minimizing the production of glucagon, Beinaglutide diligently strives to enhance glycemic control. Its remarkable therapeutic capabilities empower individuals with type 2 diabetes to gracefully navigate the boundless complexities of comprehensive glucose management.
CAT No: R2016
CAS No:123475-27-4
Chemical Name:(4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[2-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid
Beinaglutide is a synthetic peptide that functions as a glucagon-like peptide-1 (GLP-1) receptor agonist, structurally modeled after endogenous incretin hormones. As a member of the peptide compound category, it exhibits high sequence homology with human GLP-1, enabling it to mimic key physiological actions in metabolic regulation. Its biochemical properties and receptor selectivity have made it a valuable tool for researchers investigating peptide-mediated signaling pathways, metabolic homeostasis, and receptor pharmacology. Due to its potent agonistic activity and well-characterized mechanism of action, beinaglutide is widely recognized within the fields of endocrinology, peptide research, and metabolic biology for its utility in elucidating peptide hormone functions and receptor interactions.
Metabolic pathway studies: Beinaglutide is frequently employed in basic research to dissect the molecular underpinnings of glucose metabolism and energy balance. By serving as a GLP-1 receptor agonist, it enables scientists to explore the downstream signaling cascades activated by incretin hormones, including cyclic AMP production, protein kinase A activation, and modulation of insulin secretion. These investigations provide critical insights into the complex regulatory networks governing glucose homeostasis and inform the development of novel strategies for managing metabolic disorders at the molecular level.
Peptide-receptor interaction analysis: The compound is an indispensable reagent for probing the structural and functional dynamics of peptide-receptor interactions, particularly within the class B G protein-coupled receptor (GPCR) family. Researchers utilize beinaglutide to characterize ligand binding affinities, receptor conformational changes, and intracellular signaling profiles. Such studies are instrumental in mapping the pharmacological landscape of GLP-1 receptor agonists and in advancing the rational design of next-generation peptide therapeutics with enhanced selectivity and efficacy.
Cell-based assay development: Beinaglutide is widely integrated into cell-based assay platforms to evaluate receptor activation, signal transduction pathways, and functional responses in vitro. Its defined agonistic properties make it a reliable positive control or reference compound for validating assay sensitivity and specificity. Through these applications, it supports the optimization of high-throughput screening protocols and the identification of novel modulators of GLP-1 receptor activity, thereby accelerating drug discovery and biochemical research efforts.
Peptide structure-activity relationship (SAR) studies: As a synthetic analog with well-characterized activity, beinaglutide is a valuable standard for comparative structure-activity relationship investigations. Researchers employ it to systematically assess how specific amino acid substitutions, sequence modifications, or chemical modifications influence biological activity, receptor affinity, and metabolic stability. These SAR studies are essential for guiding the engineering of optimized peptide ligands and for expanding the fundamental understanding of the determinants of peptide function.
Analytical method validation: The compound is also utilized in the validation and calibration of analytical methods designed to quantify peptide hormones and their analogs in complex biological matrices. Its known properties and stability enable researchers to develop and refine techniques such as liquid chromatography-mass spectrometry (LC-MS) and immunoassays. These validated methods are critical for accurate measurement of GLP-1 analogs in pharmacokinetic, pharmacodynamic, and metabolic studies, supporting robust data generation and reproducibility in peptide research.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
4. Myotropic activity of allatostatins in tenebrionid beetles
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